The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms [Microbiology]

Following mycobacterial entry into macrophages the ESX-1 type VII secretion system promotes phagosomal permeabilization and type I IFN production, key features of tuberculosis pathogenesis. The current model states that the secreted substrate ESAT-6 is required for membrane permeabilization and that a subsequent passive leakage of extracellular bacterial DNA into the...

Source: Proceedings of the National Academy of Sciences - January 13, 2020 Category: Science Authors: Julia Lienard, Esther Nobs, Victoria Lovins, Elin Movert, Christine Valfridsson, Fredric Carlsson Tags: Biological Sciences Source Type: research