The circadian clock protein REVERB{alpha} inhibits pulmonary fibrosis development [Medical Sciences]

Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrotic tissue. These changes result from an infiltration...

Source: Proceedings of the National Academy of Sciences - January 13, 2020 Category: Science Authors: Peter S. Cunningham, Peter Meijer, Alicja Nazgiewicz, Simon G. Anderson, Lee A. Borthwick, James Bagnall, Gareth B. Kitchen, Monika Lodyga, Nicola Begley, Rajamiyer V. Venkateswaran, Rajesh Shah, Paul F. Mercer, Hannah J. Durrington, Neil C. Henderson, Ka Tags: Biological Sciences Source Type: research