Researchers Find Potential New Target for Mesothelioma Treatment

An international research team has identified a novel molecular target with potential to significantly improve future treatment of malignant pleural mesothelioma. The recent findings could lead to a drug that targets key genetic inhibitors often preventing a patient’s own immune system from suppressing mesothelioma tumor growth. Dr. Antonio Giordano, part of the collaborative research team, said the goal is reducing mesothelioma mortality with a combinational therapy that includes this new target. “These findings help us define molecular mechanisms that may be key to mesothelioma aggressiveness and progression,” Giordano told The Mesothelioma Center at Asbestos.com. “Knowing which pathways to target will help us improve treatments and patient survival. This is the starting point.” Giordano, pathologist and geneticist, is the founder and director of the Sbarro Health Research Organization at Temple University in Philadelphia. He also is an internationally renowned professor of pathology at the University of Siena in Italy. Oncologist Dr. Raffaella Pippa at the University of Navarra in Pamplona, Spain, and Dr. Silvia Boffo at the Sbarro Institute for Cancer Research are co-authors of the study. The Journal of Cellular Physiology published the findings in December. Clinical Trials Are Next Step Giordano believes the recent findings will lead to future clinical trials, where a new treatment combination for mesothelioma may be developed. Mesothelioma ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
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Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
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Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
Helicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Aging ‐associated risk factors should be considered. Future studies, related to aging andH. pylori infection with extragastric disease can help to provide vivid evidences. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non ‐gastric pathologies. Aging‐associated cellular and molecular alteration can increase the ris...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
ConclusionIn summary, the above results indicate thatXIST promotes colorectal cancer tumorigenesis by regulating miR ‐93‐5p/HIF ‐1A/AXL signaling pathway, which will supply a novel perspective to diagnose and treat colorectal cancer disease.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: Available online 26 February 2020Source: Urology Case ReportsAuthor(s): Tomoko Yonamine, Tadashi Kaname, Yasutsugu Chinen, Kouichi Tamashiro, Noritake Kosuge, Seiichi Saito
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionChronic inflammation in the dorsolateral prostate of rats dosed with EB, T and E resulted in deregulated expression in a set of microRNAs whose target genes were related to tumor growth or abnormal proliferation. Our findings suggest the identified microRNAs and their target genes the potential use as biomarkers to predict prostate cancer development. Validation using human samples is warranted.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Discussion and conclusionsA schema showing the time from initiation of therapy at which specific antineoplastic agents can cause significant levels of genetic damage in conceptuses and live offspring was developed. The estimates and methods for computing the level of such risk from an individual patient's treatment regimen will enable patients and counselors to make informed decisions on the use of spermatozoa or continuation of a pregnancy.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: REVIEW ARTICLE Source Type: research
Publication date: Available online 26 February 2020Source: European UrologyAuthor(s): Wei Liu, Xiaoping Liu, Sheng Li
Source: European Urology - Category: Urology & Nephrology Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
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