A direct immunohistochemistry (IHC) method improves the intraoperative diagnosis of breast papillary lesions including breast cancer.

A direct immunohistochemistry (IHC) method improves the intraoperative diagnosis of breast papillary lesions including breast cancer. Discov Med. 2019 Aug;28(152):87-93 Authors: Dai W, Zhong L, He J, Zhao Y Abstract Tumors with the attributes of rapid growth, infiltration, and metastasis are the leading causes of death among cancer patients. Angiogenesis is essential to tumor nutrition support and tumor progression. Endoglin is a glycoprotein highly expressed on the endothelial cell membrane and is regarded as the most reliable marker of tumor vascular proliferation. In this review, we summarize recent advances in targeting endoglin for the imaging of cancer angiogenesis and the development of monoclonal antibodies and vaccines to inhibit cancer angiogenesis. In addition, we forecast the future promise of endoglin as a novel target for the diagnosis and treatment of malignant tumors. PMID: 31926580 [PubMed - in process]
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research