Immune-related Adverse Events Associated With Checkpoint Inhibition in the Setting of CAR T Cell Therapy: A Case Series

ConclusionsT cell exhaustion has been suspected to contribute to poor persistence of CAR T-cells and clinical relapse, which may be overcome by checkpoint inhibition. While the synergy between CAR T-cell therapy and checkpoint inhibition is promising, the interaction may also lead to off-target irAEs. Prospective trials exploring the safety and efficacy of this combination in relapsed/refractory DLBCL are under way.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: Available online 24 February 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Ming-Yue Duan, Ming Li, Hui Tian, Gen Tang, Yu-Cong Yang, Nian-Cai Peng
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Abstract TCM-based medications have been used for millennia in China and have always been "different" from current Western-based medicines in that they frequently are still mixtures of predominately plant products. From the early 20th Century, there has been a move to identify both the actual compounds in these mixes, and then over the past approximately 50years, to utilize early information for current diseases, with an example being artemisinin for treatment of malaria. Since that discovery, Western scientists, together with their Chinese counterparts, have begun to investigate how TCM compositions can...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
Patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who achieved complete or partial response to tisagenlecleucel may also experience improvements in health-related quality of life (HRQoL), a phase 2 trial reveals.Reuters Health Information
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Hematology-Oncology News Source Type: news
This study was aimed to evaluate the survival benefit of surgical excision in PCNSL patients based on a US population. Using the Surveillance, Epidemiology, and End Results (SEER) Program database, a total of 3,543 PCNSL patients were identified from 2000 to 2014 for analysis. Surgical excision was accessed via Kaplan–Meier and multivariate Cox regression survival analyses. Coarsened exact matching (CEM) analysis was additionally employed to intensify our findings. Finally, we found that surgical excision was significantly associated with increased survival over no surgery/biopsy (P
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 25 February 2020Source: Annals of Medicine and SurgeryAuthor(s): Alam Ara Shafi, Nourah Bin Saad, Bandar AlHarthi
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 24 February 2020Source: The Lancet HaematologyAuthor(s): Christopher P Fox, Monica Civallero, Young-Hyeh Ko, Martina Manni, Tetiana Skrypets, Stefano Pileri, Seok Jin Kim, Maria Elena Cabrera, Andrei R Shustov, Carlos S Chiattone, Steven M Horwitz, Ivan Dlouhy, Michele Spina, Felicitas Hitz, Silvia Montoto, Arnon Nagler, Virginia Martinez, Carmino A De Souza, Ruben Fernandez-Alvarez, Veronika Ballova
Source: The Lancet Haematology - Category: Hematology Source Type: research
ConclusionsT cell exhaustion has been suspected to contribute to poor persistence of CAR T-cells and clinical relapse, which may be overcome by checkpoint inhibition. While the synergy between CAR T-cell therapy and checkpoint inhibition is promising, the interaction may also lead to off-target irAEs. Prospective trials exploring the safety and efficacy of this combination in relapsed/refractory DLBCL are under way.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
In this study, we reviewed major human studies on the health risks of radiation exposure and showed that sex-related factors may potentially influence the long-term response to radiation exposure. Available data suggest that long-term radiosensitivity in women is higher than that in men who receive a comparable dose of radiation. The report on the biological effects of ionizing radiation (BEIR VII) published in 2006 by the National Academy of Sciences, United States emphasized that women may be at significantly greater risk of suffering and dying from radiation-induced cancer than men exposed to the same dose of radiation....
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently being diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto ’s thyroiditis. This case is unique as it is one of only a few case reports describing multiple autoimmune conditions in one patient with HL and in this scenario, the thromb...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders, with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto thyroiditis. This case is one of only a few case reports describing multiple autoimmune conditions in a single patient with HL.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
More News: Cancer & Oncology | Legislation | Leukemia | Lymphoma | Myeloma | Respiratory Medicine | Skin | Thyroiditis | Toxicology