Clinical features and treatment of 7 Chinese TAFRO syndromes from 96 de novo Castleman diseases: a 10-year retrospective study

ConclusionsThis study reveals that TAFRO syndrome is more severe and has more systemic symptoms than other iMCD, most cases need active treatment, and their prognoses are poor. Lenalidomide based regimen may be as a promising new therapy for TAFRO syndrome.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research

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CONCLUSION: Majority of the viewers used mobile phones, and mobile phones and tablets had significantly longer average view durations as compared to computer/TV. YouTube and wireless devices may have potential as internet based psychiatric emergency outreach platform. This study calls for further research to explore the effectiveness of using social media and wireless devices for psychiatric emergency education prior to ED arrival, particularly in minority populations with cultural barriers to health care. PMID: 32086173 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT00180E, PaperWei-Wei Qin, Zheng-Yin Pan, Daihong Cai, Yi Li, Liang He The combination of chemotherapy and photodynamic therapy in an iridium-based molecular compound is less reported. Herein, two iridium complexes (IrC1 and IrC2) with -carboline alkaloid ligands were designed and synthesized.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThree BODIPY ‐peptide conjugates designed to target the epidermal growth factor receptor (EGFR) at the extracellular domain were synthesized and their specificity for binding to EGFR was investigated. Peptide sequences containing seven amino acids, GLARLLT (2) and KLARLLT (3), and 13 amino acids, GYHWYGYTPQNVI (4), were conjugated to carboxyl BODIPY dye (1) by amide bond formation in up to 73% yields. The BODIPY ‐peptide conjugates and their “parent” peptides were determined to bind to EGFR experimentally using SPR analysis, and were further investigated using computational methods (AUTODOCK). Resul...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
ConclusionThis large cohort confirms the severity of G ‐TMA, associated with severe renal failure and death. Edema and hypertension could be monitored in patients treated with Gemcitabine to detect early TMA. The benefit of PE or Eculizumab deserves further investigation.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractIntroductionPatients with light chain myeloma frequently have a light chain tubular cast nephropathy, which can lead to severe renal impairment. In the present retrospective study, bortezomib was combined with other active substances like bendamustine and prednisone (BPV), in order to assess the efficacy and toxicity of the combination therapy in patients with light chain multiple myeloma.MethodsBetween September 2008 and May 2015, 25 patients with newly diagnosed light chain multiple myeloma were treated with bendamustine 60  mg/m2 on days 1 and 2, bortezomib 1.3  mg/m2 on days 1, 4, 8 and 11, and predni...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Amol T Kothekar, Vijaya Patil, Nambiraj Konar, Jigeeshu DivatiaIndian Journal of Critical Care Medicine 2017 21(6):391-393A 60-year-old apparently healthy female patient underwent mastectomy for breast cancer. She had sinus tachycardia and no other abnormal finding in the preoperative period. However, the immediate postoperative course was stormy with the development of anemia, thrombocytopenia, hemolysis, and renal failure with severe metabolic acidosis. Peripheral blood smear revealed the presence of ring forms of Plasmodium falciparum. Multiorgan failure and death occurred within 36 h of surgery in spite of initiation o...
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
AbstractTaiwan is a well-known endemic area of hepatitis B. Hepatocellular carcinoma (HCC) has consistently been the first or second highest cause of cancer death over the past 20 years. This review article describes the progress of liver resection for HCC in Taiwan in the past half century. The mortality rate for HCC resection was 15 –30% in Taiwan in the 1970s. The rate decreased to 8–12% in the early 1990s, and it declined to
Source: Japanese Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: The reasons for the unpredictable, severe toxicity of the IXB/TEM combination are unclear. The MTD could not be determined, and enrollment was discontinued. This trial exemplifies challenges associated with development of drug combinations with mTOR inhibitors.Supported in part by UM1 CA186686 and P30 CA15083. Clinical trial information: NCT01375829Citation Format: Joel M. Reid, Michael E. Menefee, Felix Boakye-Agyeman, Chad A. Walden, Charles Erlichman, Keith C. Bible. Phase I and pharmacokinetic study of ixabepilone and temsirolimus in adult patients with advanced solid tumors. [abstract]. In: Proceedings of...
Source: Molecular Cancer Therapeutics - Category: Cancer & Oncology Authors: Tags: mTOR / PI3-Kinase: Poster Presentations - Proffered Abstracts Source Type: research
This report will certainly help to clarify the pathogenesis of and optimal treatment strategies for TAFRO syndrome. PMID: 26250536 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Abstract Gefitinib was compared with pemetrexed as maintenance therapy in Patients with Advanced Glandular Non-small Cell Lung Cancer, mainly regarding clinical effect and side effect. A randomized trial of pemetrexed as study group (500 mg/m(2), dl) versus gefitinib as the control group [250 mg on night 1, 250 mg on morning 2 (every day)] was conducted in 188 patients, 94 cases in each group with a therapy cycle of 21 days. In addition, the study group was also treated with folic acid, vitB12 and dexamethasone. Therapeutic effects and adverse reactions of the two groups were compared. Patients of two groups compl...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Int J Clin Exp Med Source Type: research
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