The effects of remifentanil used during cesarean section on oxidative stress markers in correlation with maternal hemodynamics and neonatal outcome: a randomized controlled trial

Publication date: November–December 2019Source: Brazilian Journal of Anesthesiology (English Edition), Volume 69, Issue 6Author(s): Marija S. Kutlesic, Gordana Kocic, Ranko M. KutlesicAbstractBackground and objectiveRemifentanil is used to attenuate maternal hemodynamic response to intubation and surgical stress during Induction–Delivery period of cesarean section. The goal was to compare the effects of two remifentanil dosing regimens on oxidative stress level, in correlation with its hemodynamic and neonatal effects.MethodsFifty-one patients, 17 per group, enrolled for elective cesarean section were randomly divided by computer-generated codes into three parallel groups: (A) patients received a 1 μg.kg−1 remifentanil bolus immediately before induction, followed by 0.15 μg.kg−1.min−1 infusion, that was stopped after skin incision; (B) patients received a 1 μg.kg−1 remifentanil bolus immediately before induction; (C) (control), patients did not receive remifentanil until delivery. Maternal venous blood samples were taken at basal time, at extraction and 30 minutes after the end of operation for spectrophotometrical determination of malondialdehyde and advanced oxidation protein products concentration. The same was conducted for umbilical venous sample.ResultsSystolic blood pressure and heart rate remained significantly lower in group A compared to B and C during entire Induction–Delivery period (p 
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research

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We report the case of a pregnant patient diagnosed with Cockayne Syndrome, submitted successfully to spinal anesthesia for a cesarean section due to cephalopelvic disproportion. In view of the difficult decision between inducing general anesthesia in a patient with a likely difficult airway, or neuraxial anesthesia in a patient with cardiovascular, respiratory and neurocognitive limitations, we suggest tailored management to reach the best results for the mother and newborn.ResumoA síndrome de Cockayne é doença multissistêmica autossômica recessiva devido à falha no reparo do DNA. Or...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
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We describe a successful case of a pregnant patient with type I hereditary angioedema submitted to a C-section.ResumoO angioedema hereditário é uma doença autossômica dominante, que se manifesta por crises súbitas, recorrentes e de gravidade variável de edema subcutâneo e submucoso, que podem ocorrer espontaneamente ou em resposta a gatilhos. São conhecidos três tipos de angioedema hereditário. A doença é condicionada por diminuição do nível plasmático ou alteração da capacidade funcional do inibidor d...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
CONCLUSIONS Intrathecal DEX is safe for the fetus during cesarean section and can improve the blockade effects of spinal anesthesia on puerperae. PMID: 31995551 [PubMed - in process]
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Combined spinal-epidural anesthesia (CSEA) can be performed with either a single-space technique or a double-space technique for cesarean section. We performed a double-blind randomized controlled study to com...
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Condition:   Caesarean Section;Stillbirth Intervention:   Sponsor:   Centre Hospitalier Universitaire de NÄ«mes Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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