Oral Dimethyl Fumarate Reduces Peripheral Neuropathic Pain in Rodents via NFE2L2 Antioxidant Signaling
Conclusions Dimethyl fumarate, a nonopioid and orally-bioavailable drug, alleviated nociceptive hypersensitivity induced by peripheral nerve injuryvia activation of NFE2L2 antioxidant signaling. Dimethyl fumarate also resolved neuroinflammation and mitochondrial dysfunction —oxidative stress-dependent mechanisms that drive nociceptive hypersensitivity after nerve injury.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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