Genetic variants associated with psychotic symptoms across psychiatric disorders

DiscussionCACNA1C rs11615998 was associated with psychotic symptoms (C-allele carriers have decreased psychotic-risk) independently from the diagnosis, in line with the evidence of a cross disorder effect of many risk variants. This gene was previously associated with SCZ and cross-disorder liability to psychiatric disorders. Our findings confirmed that deep phenotyping is pivotal to clarify the role of genetic variants on symptoms patterns.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research

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This article summarizes the milestones in the development of lumateperone leading to this first approval for the treatment of schizophrenia.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms-Clinician rated scale (IDS-C). ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Today Gabe speaks with the president and CEO of PsychHub.com, Marjorie Morrison.  Psych Hub is a partner of PsychCentral.com and has more than 100 free animated videos on a variety of mental health, substance use, and suicide prevention topics. Join us as Marjorie explains how Psych Hub got started, what types of videos they have, how to find credible information in the internet age, and how for some, animated videos can be the best choice for an information source. SUBSCRIBE &REVIEW Guest information for ‘Video Library Documenting Mental Health’ Podcast Episode Marjorie Morrison is the president a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders General Interview Mental Health and Wellness Podcast Psychiatry Psychology Self-Help Technology The Psych Central Show Source Type: blogs
   Today we are joined by Dr. Russell Morfitt, co-founder of LearntoLive.com.  Dr. Morfitt explains the differences between stress, worry, anxiety, social anxiety, and panic, and tell us how using the techniques of Cognitive Behavioral Therapy (CBT) can be life changing.  The Learn to Live program is designed to teach CBT skills online to anxiety sufferers, those who suffer from depression, and even insomniacs!  Listen in to learn how you can begin to free yourself from the burdens of anxiety.  SUBSCRIBE &REVIEW   Guest information for ‘Anxiety, Stress, and Worry’ Podcas...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Self-Help Stress The Psych Central Show Source Type: blogs
Authors: Geoffroy PA, Micoulaud Franchi JA, Lopez R, Schroder CM, membres du consensus Mélatonine SFRMS Abstract Melatonin is a hormone secreted by the pineal gland at night. This hormone has many physiological functions, the main one being to synchronise individuals' biological rhythms. Exogenous melatonin has the same chronobiotic action, even at small doses (0.125mg). In addition, a sleep-inducing (soporific) action appears to occur in a dose-effect relationship, i.e. as the dose increases. In psychiatric disorders, these two effects could have interesting applications in clinical practice. The French ins...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
CONCLUSIONS: Our results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference. PMID: 31234011 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
In conclusion, this review highlights the importance for clinicians to investigate for the presence of chronic nightmares along with other sleep difficulties (most commonly, insomnia and sleep apnea), to consider the potential influence of nightmares on the course of the primary mental disorder, and to be prepared to grant access to treatments targeting nightmares. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Dreaming - Category: Psychiatry & Psychology Source Type: research
ConclusionsOur results suggest a causal role of insomnia in autism spectrum disorder and bipolar disorder. Future disease models should include insomnia as a factor for these two disorders to develop effective interventions. More detailed mechanism studies may also be inspired by this causal inference.
Source: European Psychiatry - Category: Psychiatry Source Type: research
In conclusion. In conclusion, if you want to have a good prosperous life, practice good sleep hygiene and make Gabe happy because he really likes this topic. Everyone, if you like A Bipolar, a Schizophrenic, and a Podcast, subscribe to us on iTunes. Listen to us everywhere, write us a review, give us five stars, tell us you love us, tell the world you love us, share everything. We love you and we hope you love us. Thank you everybody. Announcer: You’ve been listening to A Bipolar, a Schizophrenic, and a Podcast. If you love this episode, don’t keep it to yourself head over to iTunes or your preferred podcast ap...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Depression Schizophrenia Sleep Source Type: blogs
Rui Yan1, ShiWan Tao1, HaiYan Liu1, Yu Chen1, JiaBo Shi1, YuYin Yang1, RongXin Zhu1, ZhiJian Yao1,2* and Qing Lu3,4*1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China2Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing, China3School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China4Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackground: Major depressive disorders often involve somatic symptoms and have been found to have fundamental differences from non-somatic depressi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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