Drug designed to break up PHLEGM for patients with bronchitis 'could slow down Parkinson's

Researchers at University College London and the Royal Free Hospital tested ambroxol on 17 Parkinson's sufferers over six months. Results were published in the journal JAMA Neurology.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusions: Tai Chi may be beneficial for improving balance and reducing falls in older people and those with Parkinson disease. Because of limitations and inconsistent conclusions, further rigorous, normative and comprehensive SRs are needed to provide robust evidence for definitive conclusions.
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
In this study, we used infectious bronchitis coronavirus (IBV) as a model to study EIC. Two recombinant IBVs (rIBVs) harboring EIC-inactivating mutations – rT16A and rA26F – were serially passaged, and several compensatory mutations were identified in the transmembrane domain (TMD). Two rIBVs harboring these putative EIC-reverting mutations – rT16A/A26V and rA26F/F14N – were recovered. Compared with the parental rIBV-p65 control, all four EIC mutants exhibited comparable levels of intracellular RNA synthesis, structural protein production, and virion assembly. Our results showed that the IBV EIC con...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionAccording to the notable anti-inflammatory effect in vitro and its joint protective effects on a septic mouse model, SESLA might act as an adjuvant drug candidate for sepsis, even those caused by antibiotic-resistant bacteria, e.g., CRKP.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Parkinson;   Parkinson Disease;   Gait Disorders, Neurologic;   Parkinsonism;   Gait, Festinating Intervention:   Device: repetitive transcranial magnetic stimulation Sponsors:   Fondazione Europea di Ricerca Biomedica Ferb Onlus;   University of Kiel;   Università degli Studi di Brescia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 January 2020Source: Life SciencesAuthor(s): Ya-Shuo Feng, Si-Dong Yang, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng ZhangAbstractParkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect ...
Source: Life Sciences - Category: Biology Source Type: research
Scientists recently tested probiotics in a roundworm model of Parkinson ’s. A particular bacterium had a protective effect and improved symptoms.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news
(University of British Columbia) Living near major roads or highways is linked to higher incidence of dementia, Parkinson's disease, Alzheimer's disease and multiple sclerosis (MS), suggests new research published this week in the journal Environmental Health.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 21 January 2020Source: Neuroscience LettersAuthor(s): Jinzhao Gao, Jijun Teng, Zongchao Liu, Min Cai, Anmu XieAbstractThe relationships between vitamin D receptor (VDR) gene polymorphisms, particularly ApaI, BsmI, FokI, and TaqI, and Parkinson's disease (PD) has received increasing attention in the research community. However, as the results yielded by this increased research have hitherto conflicted, we performed an updated meta-analysis of reports on the relationships between VDR polymorphisms and PD published before October 2019 that we collected from the PUBMED, EMBASE, EBSCO, China N...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In this study, midbrain-like organoids were yielded from hPSCs to prepare cells suitable for PD therapy. Neural stem/precursor cells (NSCs) isolated from midbrain organoids (Og-NSCs) expanded stably and differentiated into mDA neurons, and an unprecedentedly high proportion express midbrain-specific factors.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 21 January 2020Source: Artificial Intelligence in MedicineAuthor(s): Kostas M. Tsiouris, Spiros Konitsiotis, Dimitrios D. Koutsouris, Dimitrios I. FotiadisAbstractTracking symptoms progression in the early stages of Parkinson’s disease (PD) is a laborious endeavor as the disease can be expressed with vastly different phenotypes, forcing clinicians to follow a multi-parametric approach in patient evaluation, looking for not only motor symptomatology but also non-motor complications, including cognitive decline, sleep problems and mood disturbances. Being neurodegenerative in nature, ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
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