Early Post-Transplantation Spirometry Is Associated with the Development of Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplantation

Bronchiolitis obliterans syndrome (BOS) is a devastating complication of allogeneic hematopoietic cell transplantation (allo-HCT), associated with significant morbidity and mortality. BOS is usually not diagnosed until a patient presents with respiratory symptoms, at which point airflow obstruction is already advanced [1,2]. Detecting an early decline in lung function is challenging, because it is often asymptomatic [3,4]. Once established, patients can experience progressive and irreversible respiratory impairment, repeated lung infections, and increased risk of nonrelapse mortality [5-7].

Source: Biology of Blood and Marrow Transplantation - December 6, 2019 Category: Hematology Authors: Kareem Jamani, Qianchuan He, Yang Liu, Chris Davis, Jesse Hubbard, Gary Schoch, Stephanie J. Lee, Ted Gooley, Mary E.D. Flowers, Guang-Shing Cheng Source Type: research