Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation

Epigenetic regulation has a profound influence on stem cell fate during normal development in maintenance of physiologic tissue homeostasis. Here we report diminished ten-eleven translocation (TET) methylcytosine dioxygenase expression and loss of the DNA hydroxymethylation mark 5-hydroxymethylcytosine (5-hmC) in keratinocyte stem cells and transit amplifying cells in human psoriasis and in imiquimod-induced murine psoriasis. Loss of 5-hmC was associated with dysregulated keratinocyte stem cell kinetics, resulting in accumulation of nestin and FABP5-expressing transit amplifying cells to produce classic psoriatic epidermal architecture.

Source: Journal of Investigative Dermatology - December 10, 2019 Category: Dermatology Authors: Feng Li, Christine W. Yuan, Shuyun Xu, Tingjian Zu, Yvon Woappi, Catherine A.A. Lee, Phammela Abarzua, Michael Wells, Matthew R. Ramsey, Natasha Y. Frank, Xunwei Wu, Anna Mandinova, Markus H. Frank, Christine G. Lian, George F. Murphy Tags: Original Article Source Type: research