Breast implant-associated anaplastic large cell lymphoma: A Comprehensive Review

During the last two decades, the number of breast implants used in aesthetic, oncologic and risk reducing surgery has exponentially increased. Since the identification of the first case of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) more than twenty years ago [1], several cases on this very rare disease have been reported, demonstrating a clear association with breast implants. As a result, the World Health Organization (WHO) recognized BIA-ALCL as a disease associated with excellent outcomes in the 2017 classification of haemato-lymphoid neoplasms [2].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research

Related Links:

Extranodal marginal zone lymphoma of mucosa ‐associated lymphoid tissue (MALT) in the thymus is a rare disease. Furthermore, amyloid deposition in thymic MALT lymphoma has not been previously described. Here, we report a case of a 35‐year‐old man with thymic MALT lymphoma with amyloid deposition and myasthenia gravis. Chest computed tom ography revealed an anterior mediastinal mass with internal cystic component and extensive calcification. Total thymectomy was performed and histopathologic findings were compatible with a diffuse amyloid deposition in extranodal marginal zone MALT lymphoma. The results indicate that ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
AbstractA 54-year-old woman finished the treatment for chronic hepatitis C and achieved sustained virological response. She was identified with some tumor lesions at her liver during follow-up observation by ultrasonography. From contrast-enhanced computed tomography, there were four tumors at sub-segment 4/5, S5, S6, and S7. These lesions are slightly enhanced on arterial phase and washed out on delayed phase. Contrast-enhanced magnetic resonance imaging showed slight enhancement on arterial phase and defect on hepatocyte phase. Tumor markers including alpha fetoprotein, Des-Gamma-Carboxy Prothrombin, carcinoembryonic ant...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
Dr. Hamori recently addressed concerns over BIA-ALCL in this video." ALCL (Anaplastic large cell lymphoma) is a very rare disease, found in approximately one in 30,000 patients. So, while there is a lot of hype about it right now, and while I think it is important that women are aware of it, it is also creating a lot of panic for a disease that is quite uncommon.First of all, it affects only people who have textured implants — implants that have a little pebbling on the outside. The theory is that after seven or eight years contamination can occur, some over reactive immune response occurs, a fluid film for...
Source: What's New In Plastic Surgery? - Category: Cosmetic Surgery Tags: bia-alcl breast implant disease Source Type: blogs
MALT lymphoma is an indolent disease with favorable treatment outcomes. There was no significant difference in overall survival between patients treated with and without surgical resection, but surgery still plays an important role in the diagnosis and treatment of MALT. AbstractPrimary pulmonary mucosa ‐associated lymphoid tissue‐derived (MALT) lymphoma is a rare disease with a favorable prognosis. However, its clinical characteristics, diagnosis, treatment, and prognoses remain unclear. We retrospectively analyzed 80 patients with pathologically confirmed MALT lymphoma from 2006 to 2018. The clinical characteristics,...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSION: This is the first study to examine such a large library of clinically approved compounds for the identification of novel drug candidates for MCL treatment, the results could be rapidly translated into clinical practice in patients with MCL. PMID: 31526347 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
(WASHINGTON) — Breast implant maker Allergan Inc. issued a worldwide recall Wednesday for textured models because of a link to a rare form of cancer. The U.S. Food and Drug Administration said it called for the removal after new information showed Allergan’s Biocell breast implants with a textured surface account for a disproportionate share of rare lymphoma cases. The move follows similar action in France, Australia and Canada. The FDA is not recommending women with the implants have them removed if they are not experiencing problems. Biocell implants feature a textured surface designed to prevent slippage and...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer onetime Source Type: news
ABSTRACT Angiosarcomas are a rare group of tumours which have poor prognosis and limited treatment options. The development of new therapies has been hampered by a lack of good preclinical models. Here, we describe the development of an autochthonous mouse model of angiosarcoma driven by loss of p53 in VE-cadherin-expressing endothelial cells. Using Cdh5-Cre to drive recombination in adult endothelial cells, mice developed angiosarcomas with 100% penetrance upon homozygous deletion of Trp53 with a median lifespan of 325 days. In contrast, expression of the R172H mutant p53 resulted in formation of thymic lymphomas wit...
Source: DMM Disease Models and Mechanisms - Category: Biomedical Science Authors: Tags: Cancer, Rare diseases RESEARCH ARTICLE Source Type: research
In the past few blogs, I've been discussing the recent publication of my book,Evolution ’s Clinical Guidebook: Translating Ancient Genes Into Precision Medicine. The premise of this book is that modern medicine is based on an understanding of evolutionary processes. Evolution shows us the relationships between the subdisciplines of medicine that benefit directly from Precision Medicine (i.e., pathology, microbiology, clinical genetics, pharmacology, and bioinformatics). In Evolution's Clinical Guidebook, all of these diverse fields are brought together, under the subject of evolution. To illustrate, I have listed bel...
Source: Specified Life - Category: Information Technology Tags: bioinformatics clinical genetics evo-devo evolution precision medicine rare disease Source Type: blogs
ConclusionThe distribution of registered semiconductor workers with cancer and rare diseases was closely related to the manufacturing era prior to 2005, ≤8 inches wafer size handled, exposure to clean rooms of fab and chip assembly operations, and etching operations.
Source: Safety and Health at Work - Category: Occupational Health Source Type: research
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
More News: Breast Augmentation | Cancer | Cancer & Oncology | International Medicine & Public Health | Lymphoma | Plastic Surgery | Rare Diseases | WHO