Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome

Kabuki syndrome (KS) is commonly caused by mutations in the histone-modifying enzyme lysine methyltransferase 2D (KMT2D). Immune dysfunction is frequently observed in individuals with KS, but the role of KMT2D in immune system function has not been identified.

Source: Journal of Allergy and Clinical Immunology - December 5, 2019 Category: Allergy & Immunology Authors: Genay O. Pilarowski, Tareian Cazares, Li Zhang, Joel S. Benjamin, Ke Liu, Sajjeev Jagannathan, Nadeem Mousa, Jennifer Kasten, Artem Barski, Andrew W. Lindsley, Hans T. Bjornsson Source Type: research