Reciprocal copy number variations at 22q11.2 produce distinct and convergent neurobehavioral impairments relevant for Schizophrenia and Autism Spectrum Disorder

22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these reciprocal CNVs in conjunction with brain imaging measures have not been reported.

Source: Biological Psychiatry - January 12, 2020 Category: Psychiatry Authors: Amy Lin, Ariana Vajdi, Leila Kushan-Wells, Gerhard Helleman, Laura Pacheco Hansen, Rachel K. Jonas, Maria Jalbrzikowski, Lyle Kingsbury, Armin Raznahan, Carrie E. Bearden Tags: Archival Report Source Type: research