Polyetherimide/polyvinylpyrrolidone hollow-fiber membranes for use in hemodialysis
In this study, polyetherimide/polyvinylpyrrolidone (PEI/PVP) hollow fiber membranes (HFMs) were synthesized by the phase inversion method. The synthesized PEI/PVP membranes were characterized by morphological analysis and transport properties (hydraulic permeability and solute rejection coefficient). Their performance in uremic solutes separation was also investigated. Urea removal and clearance were measured. Surface properties were analyzed by infrared spectroscopy (FT-IR), water uptake, zeta potential and protein adsorption. The results showed that PEI/PVP membranes had transport properties comparable to those of current high flux clinical membranes, with better removal of medium molecular weight solutes (using lysozyme as a model) and high retention of high molecular weight solutes (using albumin as a model). Surface characterization suggests that PEI/PVP membranes present improved blood compatibility. These results confirm the potential of polyetherimide as an alternative material for producing hollow fiber hemodialyzers, in substitution to polysulfone and polyethersulfone.
Authors: Somji SS, Ruggajo P, Moledina S Abstract The worldwide prevalence of maintenance hemodialysis continues to rise. An adequate delivery of hemodialysis dose as measured by Kt/V or urea reduction ratio is a crucial determinant of clinical outcome for chronic hemodialysis patients. The aim of this study was to assess the adequacy of hemodialysis and its associated factors among patients undergoing chronic hemodialysis in Dar es Salaam. This was a cross-sectional study done on patients undergoing chronic hemodialysis in four dialysis centers in Dar es Salaam. Sociodemographic information and treatment character...
Authors: Medeiros MC, Rocha N, Bandeira E, Dantas I, Chaves C, Oliveira M, Bandeira F Abstract Sclerostin (Scl) is an osteoblast-inhibiting glycoprotein that is secreted mainly by osteocytes and is regulated by hormonal changes and skeletal loading. Decreased physical function and high serum Scl concentrations have been reported in chronic renal failure patients but little is known to date about the differences between diabetic and non-diabetic patients on hemodialysis who are susceptible to both sarcopenia and bone fragility. Objective.To determine the prevalence of sarcopenia and its association with serum Scl co...
Authors: Blanco-Dominguez I, Monsalve B, Martínez LM, Oteiza AV, Bové M PMID: 32093958 [PubMed - as supplied by publisher]
Condition: Hemodialysis Access Failure Intervention: Device: Paclitaxel-eluting graft Sponsor: Samsung Medical Center Recruiting