Grading of Recommendations Assessment, Development, and Evaluations (GRADE) notes: extremely serious, GRADE's terminology for rating down by three levels

The Grading of Recommendations Assessment, Development, and Evaluations (GRADE) system for assessing certainty in a body of evidence currently uses two levels, serious and very serious, for downgrading on a single domain. In the context of newer risk of bias instruments, such as Risk of Bias in Non-Randomized Studies I (ROBINS-I), evidence generated by nonrandomized studies may justify rating down by more than two levels on a single domain. Given the importance users of GRADE assign to terminology, our objective was to assess what term GRADE stakeholders would prefer for rating down certainty by three levels.

Source: Journal of Clinical Epidemiology - December 18, 2019 Category: Epidemiology Authors: Thomas Piggott, Rebecca L. Morgan, Carlos A. Cuello-Garcia, Nancy Santesso, Reem A. Mustafa, Joerg J. Meerpohl, Holger J. Sch ünemann, GRADE Working Group Tags: Original Article Source Type: research