Assessing the efficacy and safety of laparoscopic antireflux procedures for the management of gastroesophageal reflux disease: a systematic review with network meta-analysis

ConclusionLaparoscopic 270 ° fundoplication achieves a better outcome than 360° total fundoplication, especially in terms of postoperative dysphagia, although other types of partial fundoplication might be equally effective.Registration no.CRD42017074783.
Source: Surgical Endoscopy - Category: Surgery Source Type: research

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The evolution of disease complexity often exceeds the  simplicity of its original name. For example, regional enteritis (Crohn’s disease) is anything but regional in the GI tract and is associated with a myriad of systemic manifestations. It is measured by numerous determinations, including standardized symptom and endoscopy scores, enterographic imaging, and fecal calprotectin. Gastroesophageal reflux was a disease of heartburn but now is comprehensively assessed by the Los Angeles classification, ambulatory pH/impedance monitoring, and risk stratification tools for Barrett’s esophagus.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
HEARTBURN is an extremely uncomfortable feeling which occurs if one has had too much of the wrong foods or drinks. Acid reflux, which causes heartburn, often follow overindulgence. But how can it be avoided and when could heartburn signal something more serious?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractNonerosive reflux disease (NERD) is a gastrointestinal disorder that leads to symptoms such as heartburn and regurgitation without visible esophageal mucosal injury, and it is treated with proton-pump inhibitors (PPIs). CHETOGERD® gel or orosoluble (oro) formulations —an association of natural active ingredient: hyaluronic acid, altea, malva, apple active TM,Aloe vera,l-triptophan, calcium gluconate, sodium bicarbonate,Musa paradisiaca) —may be an alternative or a coadjutant treatment in patients with NERD. The aim of the study was to evaluate, prospectively, the efficacy of CHETOGERD® gel and o...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Conclusions TIF with MUSE significantly improved symptoms at 1-year follow-up, allowing the consumption of PPIs to be stopped or halved in 90 % of patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Innovations and brief communication Source Type: research
AbstractThe most studied medical condition related with dental erosions is gastroesophageal reflux disease (GERD). The aim of this study was to assess other predictors of dental erosions besides GERD in outpatients referred for upper digestive endoscopy. In a cross-sectional study, we prospectively evaluated 235 patients who underwent upper digestive endoscopy. Patients were interviewed and examined by a trained dentist before the endoscopies, addressing dental health as well as clinical information and food intake. Dental erosion was classified using Basic Erosive Wear Examination score. Potential predictors for dental er...
Source: Odontology - Category: Dentistry Source Type: research
Authors: Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta M, Ghisa M, Cicala M, Gyawali CP Abstract Background/Aims: Impaired esophageal motility and disrupted esophagogastric junction (EGJ) on highresolution manometry (HRM) have been associated with increased reflux severity in gastroesophageal reflux disease (GERD) patients. However, there are limited data evaluating HRM parameters in proton pump inhibitors (PPI) non-responders. Methods: Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH studies performed of PPI therapy in patients with typical GERD symptoms were reviewed from ...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
Proton pump inhibitors (PPIs) have been the first line treatment for gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the efficacy of vonoprazan (VPZ), a potassium-competitive acid blocker for reflux esophagitis (RE), nonerosive reflux disease (NERD), and PPI-resistant GERD patients. An open-label, single-center, observational study in our hospital was performed from August 2016 to August 2017. All patients diagnosed with GERD were asked to self-report a questionnaire of frequency scale for the symptoms of GERD (FSSG) and rate their degree of satisfaction with the treatment of GERD during outp...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
BackgroundBased on 122 cases reported in China, data mining indicated that Sini Powder (SNP) and the Zuojin Pill (ZJP) are both widely used as the basic recipe for treating Gastroesophageal Reflux Disease (GERD).ObjectivesTo evaluate the intervention effects of Sini Zuojin Decoction (SNZJD) in patients with GERD.MethodsA comprehensive collection of randomized controlled trials (RCTs) using SNZJD in patients with GERD that were published in domestic and foreign journals was made by computer retrieval. RevMan 5.3 software was used for meta-analysis and bias risk assessment, Stata 14.0 software was used for sensitivity analys...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the healthcare system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy and safety of IW-3718, a bile acid sequestrant, as an adjunct to PPI therapy.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
Conditions:   Gastroesophageal; Reflux With Esophagitis;   Gastroesophageal Reflux;   GERD;   Heartburn;   Non-erosive Reflux Disease;   Esophagitis Intervention:   Procedure: Dietary assessment Sponsors:   Russian Academy of Medical Sciences;   Russian Science Foundation Recruiting
Source: - Category: Research Source Type: clinical trials
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