Combination Cancer Therapy is Focus of $1M Merck Research Grant Received by NCCN

NCCN has been awarded a $1M research grant from Merck &Co, Inc., that will support research of the anti-cancer agent vorinostat (Zolinza®). Vorinostat is currently used to treat progressive, persistent, or recurrent cutaneous T-cell lymphoma. This research grant will fund studies to explore the efficacy of vorinostat in combination with chemotherapy and/or radiation therapy in selected locally advanced non-metastatic cancers including non-small cell lung cancer, head and neck cancer, panc...
Source: National Comprehensive Cancer Network Oncology Research Program - Category: Cancer & Oncology Source Type: news

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Joanna Smith, 58, of Clapham, Bedfordshire, first realised something was wrong when she spotted a tiny 'ulcer' in her mouth in October last year, which then grew and became painful.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Fabio Penna, Riccardo Ballar ò, Marc Beltrà, Serena De Lucia, Lorena García Castillo, Paola Costelli
Source: Frontiers in Physiology - Category: Physiology Source Type: research
People with a history of smoking have less effective immune system, study at University of Leeds showed. Researchers stressed the importance of quitting after a diagnosis.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: Our data showed that PAA with TAZ/PIPC with a shorter duration PAA (48 h) might be recommended for RC with urinary diversion. We found that the surgical time was significantly shorter in the non-infection group. A prospective study based on our data is desirable to establish or revise PAA strategy for prophylactic medication to prevent postoperative infection after RC with urinary diversion.Urol Int
Source: Urologia Internationalis - Category: Urology & Nephrology Source Type: research
We examined two types of hepatocellular carcinoma- typical and fibrolamellar one. Our analysis revealed that DLC2 protein is not diminished in cancer tissue when compared to non-cancerous liver specimens. What is more, we observed DLC2 to be more abundantly expressed in cancer tissue, particularly in tumors with the inflammation background. In addition, we found thatDLC2 gene status was diploid in virtually all tumor samples examined. Our results indicate that DLC2 is not diminished in hepatocellular carcinoma cells. It appears that members of the DLC family, although structurally highly related, may function differently in cancer cells.
Source: European Journal of Histochemistry - Category: Biomedical Science Source Type: research
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
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Authors: Shen D, Yu X, Wu Y, Chen Y, Li G, Cheng F, Xia L Abstract INTRODUCTION: Retinoic acid X receptors play key roles in tumor cell proliferation, differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a specific RXRs agonist which has been granted by FDA approval for the clinical treatment of cutaneous T cell lymphoma (CTCL). Its cancer prevention and treatment potentials in various tumors have been under investigation over the past decade. Areas covered: This review summarizes the efficacy and underlying mechanisms of bexarotene for the treatment of multiple cancers based on...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
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