Combination Cancer Therapy is Focus of $1M Merck Research Grant Received by NCCN

NCCN has been awarded a $1M research grant from Merck &Co, Inc., that will support research of the anti-cancer agent vorinostat (Zolinza®). Vorinostat is currently used to treat progressive, persistent, or recurrent cutaneous T-cell lymphoma. This research grant will fund studies to explore the efficacy of vorinostat in combination with chemotherapy and/or radiation therapy in selected locally advanced non-metastatic cancers including non-small cell lung cancer, head and neck cancer, panc...
Source: National Comprehensive Cancer Network Oncology Research Program - Category: Cancer & Oncology Source Type: news

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Joanna Smith, 58, of Clapham, Bedfordshire, first realised something was wrong when she spotted a tiny 'ulcer' in her mouth in October last year, which then grew and became painful.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: Our data showed that PAA with TAZ/PIPC with a shorter duration PAA (48 h) might be recommended for RC with urinary diversion. We found that the surgical time was significantly shorter in the non-infection group. A prospective study based on our data is desirable to establish or revise PAA strategy for prophylactic medication to prevent postoperative infection after RC with urinary diversion.Urol Int
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Authors: Shen D, Yu X, Wu Y, Chen Y, Li G, Cheng F, Xia L Abstract INTRODUCTION: Retinoic acid X receptors play key roles in tumor cell proliferation, differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a specific RXRs agonist which has been granted by FDA approval for the clinical treatment of cutaneous T cell lymphoma (CTCL). Its cancer prevention and treatment potentials in various tumors have been under investigation over the past decade. Areas covered: This review summarizes the efficacy and underlying mechanisms of bexarotene for the treatment of multiple cancers based on...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
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