Viruses, Vol. 12, Pages 92: Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics

Viruses, Vol. 12, Pages 92: Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics Viruses doi: 10.3390/v12010092 Authors: Travis Warren Elizabeth Zumbrun Jessica M. Weidner Laura Gomba Franco Rossi Roy Bannister Jacqueline Tarrant Matthew Reed Eric Lee Jo Lynne Raymond Jay Wells Joshua Shamblin Kelly Wetzel Ginger Donnelly Sean Van Tongeren Nicole Lackemeyer Jesse Steffens Adrienne Kimmel Carly Garvey Holly Bloomfield Christiana Blair Bali Singh Sina Bavari Tomas Cihlar Danielle Porter Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD). Until recently, when successes were achieved in characterizing the efficacy of multiple experimental EVD therapeutics in humans, the only feasible way to obtain data regarding potential clinical benefits of candidate therapeutics was by conducting well-controlled animal studies. Nonclinical studies are likely to continue to be important tools for screening and development of new candidates with improved pharmacological properties. Here, we describe a natural history study to characterize the time course and order of progression of the disease manifestations of EVD in rhesus monkeys. In 12 rhesus monkeys exposed by the intramuscular route to 1000 plaque-forming units of EBOV, multip...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research