Spatially resolved proteomics in osteoarthritis: State of the art and new perspectives.

Spatially resolved proteomics in osteoarthritis: State of the art and new perspectives. J Proteomics. 2020 Jan 08;:103637 Authors: Eveque-Mourroux MR, Rocha B, Barré FPY, Heeren RMA, Cillero-Pastor B Abstract Osteoarthritis (OA) is one of the most common diseases worldwide caused by chronic degeneration of the joints. Its high prevalence and the involvement of several tissues define OA as a highly heterogeneous disease. New biological markers to evaluate the progression of the pathology and improve its prognosis are needed. Among all the different -omic strategies applied to OA, solution phase bottom-up proteomics has made an extensive contribution to the field of biomarker research. However, new technologies for protein analyses should be considered for a better understanding of the disease. This review focuses on complementary proteomic methodologies and new technologies for translational research of OA and other rheumatic pathologies, especially mass spectrometry imaging and protein imaging methods not applied by the OA community yet. PMID: 31926309 [PubMed - as supplied by publisher]
Source: Journal of Proteomics - Category: Biochemistry Authors: Tags: J Proteomics Source Type: research