Structural effects on the hesperidin properties obtained by chelation to magnesium complexes.

Structural effects on the hesperidin properties obtained by chelation to magnesium complexes. J Inorg Biochem. 2013 Aug 23;129C:35-42 Authors: Oliveira RM, de Souza Daniel JF, de Aguiar I, das Graças Fernandes Silva MF, Batista Fernandes J, Carlos RM Abstract The magnesium complex [Mg(hesp)2(phen)] (1), where hesp=hesperidin and phen=1,10'-phenanthroline, was synthesized and characterized by Elemental Analysis (C,H,N), atomic absorption and spectroscopic (FTIR, UV-visible, (1)H NMR) techniques. The congested structure facilitates the tilting and contact of the two hesperidin ligands by hydrogen bonding interactions having a stabilizer effect on the hesperidin. The hydrogen bonds are strongly affected by the solvent used which can lead to changes in the physical-chemical, luminescence and biologic properties of complex 1. Complex 1 is more hydrosoluble (S=472±3.05μgmL(-1)) and liposoluble (log P=-0.15±0.01) than free hesperidin (S=5.92±0.49μgmL(-1), log P=0.30). Oxidation of the complex in an aqueous solution and room temperature investigated by cyclic voltammetry resulted in a very stable two-electron cyclic process to form the phenoxonium neutral, cation and dication radicals. The stability of the voltammetric process indicates that the species produced are never exhausted and does not lead to changes in the coordination sphere composition. The complex was found to be a better radical scavenger for superoxide radical (IC50=68.3μM at pH...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research