Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection

Dietary long-chain ( ≥20 carbons) n-3 polyunsaturated fatty acids (PUFAs) reduce atherosclerosis and enhance macrophage autophagy activation. How macrophage autophagy impacts atherosclerotic progression, particularly when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding, is unknown.

Source: Atherosclerosis - January 11, 2020 Category: Cardiology Authors: Zhan Wang, Russel C. Sequeira, Manal Zabalawi, Jennifer Madenspacher, Elena Boudyguina, Tiantong Ou, Jonathan M. Nelson, Yan Nie, Qingxia Zhao, Michael B. Fessler, Xuewei Zhu Source Type: research