Headache intensity is associated with increased white matter lesion burden in CADASIL patients

Publication date: Available online 11 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Miguel Tábuas-Pereira, Ricardo Varela, José Beato-Coelho, Diogo Maleita, Carlos Ferreira, Otília C. d'Almeida, César Nunes, Isabel Luzeiro, Gustavo C. SantoAbstractObjectivesCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cause of vascular dementia in adults. Migraine is a major symptom of the disease. We aimed to identify clinical and demographical features of the headache associated with increased cerebral lesion burden in a cohort of CADASIL patients.MethodsThirty-two patients with CADASIL were enrolled in this cross-sectional study. Demographics data, vascular risk factors and headache characteristics were collected through a structured questionnaire. MRI (3-T) was used to determine white matter hyperintensities burden evaluated by its volume (WMH-V).ResultsRegression analysis showed that age (β = 1.266, 95%CI = [0.805, 1.726], p 
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research

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CONCLUSION: Despite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort. PMID: 32200562 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Abstract PURPOSE: Psychological stress is a significant health problem in veterans and their family members. Traumatic brain injury (TBI) and stress lead to the onset, progression, and worsening of several inflammatory and neurodegenerative diseases in veterans and civilians. Alzheimer's disease (AD) is a progressive, irreversible neuroinflammatory disease that causes problems with memory, thinking, and behavior. TBIs and chronic psychological stress cause and accelerate the pathology of neuroinflammatory diseases such as AD. However, the precise molecular and cellular mechanisms governing neuroinflammation and ne...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is a hereditary small-vessels angiopathy caused by mutations in the NOTCH 3 gene, located on chromosome 19, usually affecting middle-ages adults, whose clinical manifestations include migraine with aura, recurrent strokes, mood disorders, and cognitive impairment leading to dementia and disability. In this review, we provide an overview of the current knowledge on the pathogenic mechanisms underlying the disease, focus on the corresponding therapeutic targets, and discuss the most promising treatment strategies currently u...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
(Loyola University Health System) TMS shows promise in treating a broad range of neurological disorders, including stroke, dementia and migraines.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Ketogenic diets have been proposed as a non-pharmacological strategy for the management of several chronic conditions. Their efficacy and safety have been evaluated in the field of neurology, oncology and endocrinology for disorders including cancer, dementia, drug-resistant epilepsy, migraines, obesity, polycystic ovary syndrome and type 2 diabetes mellitus. The nutritional requirements of these subjects are expected to differ significantly. Indeed, although all ketogenic diets restrict carbohydrates, each intervention is characterized by a specific daily calorie intake, macronutrient composition and dur...
Source: ENDOCR REV - Category: Endocrinology Authors: Tags: Rev Endocr Metab Disord Source Type: research
AbstractKetogenic diets have been proposed as a non-pharmacological strategy for the management of several chronic conditions. Their efficacy and safety have been evaluated in the field of neurology, oncology and endocrinology for disorders including cancer, dementia, drug-resistant epilepsy, migraines, obesity, polycystic ovary syndrome and type 2 diabetes mellitus. The nutritional requirements of these subjects are expected to differ significantly. Indeed, although all ketogenic diets restrict carbohydrates, each intervention is characterized by a specific daily calorie intake, macronutrient composition and duration. How...
Source: Reviews in Endocrine and Metabolic Disorders - Category: Endocrinology Source Type: research
Normal resting heart rate can vary from person to person by up to 70 beats per minute Related items fromOnMedica Good midlife heart health linked to lower dementia risk later on Patients question GPs ’ motives for prescribing statins Papworth Hospital cleared to resume heart ops Marathon running can boost vascular age Migraine may be linked to heightened cardiovascular disease risk
Source: OnMedica Latest News - Category: UK Health Source Type: news
AbstractPurpose of ReviewTranscranial magnetic stimulation (TMS) is a method of Non-Invasive Brain Stimulation that is based on electro-physical principles discovered by Michael Faraday. A TMS device is made of one or two copper coils, positioned superficially to a site of interest in the brain, to non-invasively produce a brief magnetic pulse to an estimated depth from the surface of the scalp with the following axonal depolarization. This axonal depolarization activates cortical and subcortical networks with multiple effects. There are different methods of TMS used, all with different mechanisms of action. TMS is well to...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
(University of Copenhagen The Faculty of Health and Medical Sciences) Contrary to previous belief, a neuroscientist from the Faculty of Health and Medical Sciences has shown the existence of a particular type of sphincter in the brain's blood supply in mice. The discovery changes the understanding of the blood circulation and may lead to new knowledge about migraine and dementia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
CONCLUSION: Air pollution is associated with increased risk of certain common neurological disorders. More specific studies are needed to investigate the impact of seasonal haze on neurological conditions in Southeast Asia. PMID: 32200394 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - Category: General Medicine Authors: Tags: Ann Acad Med Singapore Source Type: research
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