Age-adjusted D-dimer cutoff for the diagnosis of pulmonary embolism: a cost-effectiveness analysis.

CONCLUSIONS: The AADD cutoff results in a clinically non-significant decrease in QALY but important costs reductions. It is a decrementally cost-effective innovation, with a potential of cost savings of>$80 million per year for the United States healthcare system. PMID: 31925875 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research

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In conclusion, this study not only identifies a novel mutation of F2 and will contribute to the genetic diagnosis and counseling of families with thrombosis but also suggests that the site p.R541 of F2 may play a crucial role in thrombosis.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Study Design: This was a retrospective analysis of prospectively collected data. Objective: To investigate the incidence of thromboembolism in patients who received tranexamic acid (TXA) after lumbar spine fusion and determine the diagnostic value of lower limb duplex sonography as a screening test. Summary of Background Data: TXA is effective in reducing blood drainage in spine fusion surgery but some studies have reported increased incidence of venous thromboembolism associated with TXA. Materials and Methods: One hundred twenty-two patients who underwent lumbar fusion for degenerative spinal disease received ...
Source: Journal of Spinal Disorders and Techniques - Category: Surgery Tags: Primary Research Source Type: research
This study assessed predictors of pulmonary thromboembolism (PE) resolution and their implications for clinical outcome.MethodA total of 150 patients with acute PE diagnosed by computed tomography pulmonary angiography (CTPA) were included. All patients received anticoagulant therapy for 3 ‐6 months and were followed‐up for at least 2 years. D‐dimer levels in plasma were assayed at the first admission and during follow‐up.ResultsThe rate of CTPA ‐confirmed PE resolution was 48.67% at 6 months, 68% at 12 months, and 78.67% at 24 months. Thirty‐nine patients had recurrent thrombosis after anticoagulation therapy ...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
SummaryMR pulmonary angiography (MRPA) combined with indirect MR venography (MRV) was attempted by using 3D contrast-enhanced MR volume interpolated body examination (VIBE) sequence. Agreement rate for deep venous thrombosis (DVT) detection between MRV and duplex sonography (DUS) was evaluated; the potential of this method for venous thromoembolism (VTE) was also investigated. Thirty-four patients with DUS-identified DVT were enrolled in this study. MRI was performed after a single administration of Gadopentetate dimeglumine. Fat-suppressed 3D VIBE was applied for visualizing pulmonary arteries, abdominal veins, pelvic and...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - Category: Research Source Type: research
AbstractNon-thrombotic pulmonary embolism (NTPE) results from the embolization of non-thrombotic materials. It can often be a challenging diagnosis due to non-specific (similar to thrombotic pulmonary embolism) or uncommon clinical and imaging findings. Patients with NTPE often present to the emergency department with acute respiratory distress, and contrast-enhanced computed tomography (CT) of the chest and CT pulmonary angiography are the imaging modalities of choice for respiratory distress. Since the treatment of NTPE is entirely different from thromboembolism, its distinction is essential. Moreover, early diagnosis of...
Source: Emergency Radiology - Category: Emergency Medicine Source Type: research
We describe a case of aggressive progression of TA in an infant. This child was the youngest to be affected with the disease as reported in the literature. A 3.5-month-old boy presented with cyanosis of both legs, tachycardia and antithrombin III deficiency. Computed tomography angiography (CTA) revealed thrombosis of distal aorta and both iliac arteries. Thrombectomy was performed at the level of both common femoral arteries. In addition, thigh amputation of the left leg had to be performed. TA was diagnosed postmortem with thrombosis of the distal aorta, its branches and upper mesenteric artery which was not occluded on ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
A 46-year-old man with a history of alcohol use disorder, tobacco use, and chronic pancreatitis complicated by an untreated pseudocyst presented with two days of right lower extremity swelling and pain, shortness of breath, and pleuritic chest pain. A right lower extremity Doppler showed a saphenous vein thrombus, and CT angiography of the chest revealed multiple bilateral segmental pulmonary emboli with involvement of the right distal main pulmonary artery. The patient had no personal or family history of venous thromboembolism, and review of systems was not concerning for an underlying oncologic or active inflammatory process.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Condition:   Pulmonary Embolism Intervention:   Device: computed tomography pulmonary angiography Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Clinical scores have been proposed to stratify the risk of pulmonary thromboembolism (PTE), although this approach suffers a low specificity and the unavoidable need for computed tomography pulmonary angiography (CTPA) scans.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Original Contributions Source Type: research
Abstract Pulmonary embolism (PE) is a condition characterised by an obstruction of the pulmonary arterial system by one or more emboli. Advanced clinical practitioners are often faced with ruling out a diagnosis of PE in patients with non-specific symptoms such as dyspnoea and pleuritic chest pain, which can be fairly mild and therefore a diagnosis of PE easily missed. PEs can be a challenge to diagnose, especially in elderly people, since it can be difficult to differentiate their symptoms from other less serious illnesses. Widely used scoring tools are helpful to calculate a patient's probability of having a PE....
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
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