21st Century Approaches for Evaluating Exposures, biological activity, and risks of complex substances: Workshop highlights

Publication date: Available online 11 January 2020Source: Regulatory Toxicology and PharmacologyAuthor(s): Ursula G. Sauer, Robert A. Barter, Richard A. Becker, Emilio Benfenati, Elisabet Berggren, Bruno Hubesch, Heli M. Hollnagel, Kunifumi Inawaka, Athena M. Keene, Philipp Mayer, Kathleen Plotzke, Robert Skoglund, Océane AlbertAbstractThe June 2019 workshop 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances, co-organised by the International Council of Chemical Association's Long-Range Research Initiative and the European Commission's Joint Research Centre, is summarised. Focus was the need for improved approaches to evaluate the safety of complex substances. Approximately 10% and 20% of substances registered under the EU chemicals legislation are ‘multi-constituent substances’ and ‘substances of unknown or variable compositions, complex reaction products and biological substances’ (UVCBs), respectively, and UVCBs comprise approximately 25% of the U.S. Toxic Substances Control Act Inventory. Workshop participants were asked to consider how the full promise of new approach methodologies (NAMs) could be brought to bear to evaluate complex substances. Sessions focused on using NAMs for screening, biological profiling, and in complex risk evaluations; improving read-across approaches employing new data streams; and methods to evaluate exposure and dosimetry. The workshop concluded with facilitated discussions to explor...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research