Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice.

Conclusions: We demonstrate for the first time that miR-130b-3p enrichment in dysfunctional adipocyte-derived sEV, and its suppression of multiple anti-apoptotic/cardioprotective molecules in cardiomyocytes, is a novel mechanism exacerbating MI/R injury in the diabetic heart. Targeting miR-130b-3p mediated pathological communication between dysfunctional adipocytes and cardiomyocytes may be a novel strategy attenuating diabetic exacerbation of MI/R injury.
PMID: 31918577 [PubMed - as supplied by publisher]

Source: Circulation - January 9, 2020 Category: Cardiology Authors: Gan L, Xie D, Liu J, Lau WB, Christopher TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL, Wang Y Tags: Circulation Source Type: research