Development of Murine Systemic Lupus Erythematosus in the Absence of BAFF

ConclusionThe role of BAFF in the development of SLE ‐like disease may be dispensable as long as B cell survival is preserved via a BAFF‐independent pathway. This may help explain the limited and variable clinical success with BAFF antagonists in human SLE. Thus, NZM.Baff−/−.Bcl2Tg mice may serve as a powerful murine model for the study of BAFF ‐independent SLE.

https://www.onlinelibrary.wiley.com/doi/abs/10.1002/art.41097?af=R

Source: Arthritis and Rheumatology - December 25, 2019 Category: Rheumatology Authors: William Stohl, Ning Yu, Samantha Chalmers, Chaim Putterman, Chaim O. Jacob Tags: Original Article Source Type: research