Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.

In conclusion, both chronic and acute pancreatic inflammation in the presence of oncogenic K-ras contribute to sustained upregulation of ET axis components in the ductal and stromal cells suggesting a potential role of ET axis in the initiation and progression of PDAC. PMID: 31923844 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31923844?dopt=Abstract

Source: Neoplasia - January 6, 2020 Category: Cancer & Oncology Authors: Gupta S, Prajapati A, Gulati M, Gautam SK, Kumar S, Dalal V, Talmon GA, Rachagani S, Jain M Tags: Neoplasia Source Type: research