Compositional Framework for Multitask Learning in the Identification of Cleavage Sites of HIV-1 protease

In this study, a set of peptide data from one source is referred as ‘task’ and to integrate interactions from multiple tasks; our method exploits the common features and parameters sharing across the data source. The proposed framework uses feature integration, feature selection, multi-kernel and multifactorial evolutionary algorithm to model multitask learning. The framework considered seven different feature descriptors and four different kernel variants of support vector machines to form the optimal multi-kernel learning model. To validate the effectiveness of the model, the performance parameters such as average accuracy, and area under curve have been evaluated on the suggested model. We also carried out Friedman and post hoc statistical test to substantiate the significant improvement achieved by the proposed framework. The result obtained following the extensive experiment confirms the belief that multitask learning in cleavage site identification can improve the performance.Graphical abstract
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research