The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and the control of food intake, adiposity and body weight

ConclusionsAltogether, our results demonstrate that PRDM12 plays an essential role in the early establishment of hypothalamic melanocortin neuron identity and the maintenance of high expression levels of Pomc. Its absence in adult mice greatly impairs Pomc expression and leads to increased food intake, adiposity and obesity.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research