Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial.

Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illness: results from the IMPACT trial. World Psychiatry. 2020 Feb;19(1):69-80 Authors: Correll CU, Sikich L, Reeves G, Johnson J, Keeton C, Spanos M, Kapoor S, Bussell K, Miller L, Chandrasekhar T, Sheridan EM, Pirmohamed S, Reinblatt SP, Alderman C, Scheer A, Borner I, Bethea TC, Edwards S, Hamer RM, Riddle MA Abstract Antipsychotics are used for many psychiatric conditions in youth. Although developmentally inappropriate weight gain and metabolic abnormalities, which are risk factors for premature cardiovascular mortality, are especially frequent in youth, optimal strategies to reduce pediatric antipsychotic-induced overweight/obesity are unclear. The Improving Metabolic Parameters in Antipsychotic Child Treatment (IMPACT) was a randomized, parallel group, 24-week clinical trial which enrolled overweight/obese, psychiatrically stable youth, aged 8-19 years, with a DSM-IV diagnosis of severe mental illness (schizophrenia spectrum disorder, bipolar spectrum disorder or psychotic depression), at four US universities. All of them had developed substantial weight gain following treatment with a second-generation antipsychotic. The centralized, computer-based randomization system assigned participants to unmasked treatment groups: metformin (MET); antipsychotic switch (aripiprazole or, if alrea...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research

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Often we don’t really consider gender dynamics in treatment or medication. A lot of medications are only tested on men because of the risk of pregnancy, etc. This means there are whole drugs that have made it to market that may not have ever been tested with women. Schizophrenia affects women in many different ways than men. In this episode schizophrenic Rachel Star Withers and cohost Gabe Howard discuss differences in age, symptoms, treatments, lifestyle, parenthood in the genders as they experience schizophrenia. Dr. Hayden Finch joins to explain the medical side.  Highlights in “Schizophrenia in Women...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Mental Health and Wellness Women's Issues Gender Differences Mental Disorder Mental Illness Psychiatry Psychology Psychotherapy Women's Health women's mental health Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior General Interview Podcast Psychiatry The Psych Central Show Source Type: blogs
Publication date: Available online 23 December 2019Source: Pharmacological ResearchAuthor(s): Megan Beauchemin, Ramaz Geguchadze, Anyonya R. Guntur, Kathleen Nevola, Phuong T. Le, Deborah Barlow, Megan Rue, Calvin P.H. Vary, Christine W. Lary, Katherine J. Motyl, Karen L. HouseknechtAbstractAtypical antipsychotic (AA) medications including risperidone (RIS) and olanzapine (OLAN) are FDA approved for the treatment of psychiatric disorders including schizophrenia, bipolar disorder and depression. Clinical side effects of AA medications include obesity, insulin resistance, dyslipidemia, hypertension and increased cardiovascul...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Self-Help Stigma Source Type: blogs
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Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Disorders Inside Schizophrenia Psychiatry Source Type: blogs
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Inspiration & Hope Schizophrenia Success & Achievement Source Type: blogs
We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Chun Wu1†, Bevan E. Huang1, Guang Chen2, Timothy W. Lovenberg2, David J. Pocalyko1 and Xiang Yao3* 1Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, Spring House, PA, United States 2Neuroscience Therapeutic Area, Janssen Research &Development, LLC, La Jolla, CA, United States 3Computational Sciences, Discovery Sciences, Janssen Research &Development, LLC, La Jolla, CA, United States Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Tra...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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