SR-BI as a target of natural products and its significance in cancer

Publication date: Available online 11 January 2020Source: Seminars in Cancer BiologyAuthor(s): Dongdong Wang, Jiansheng Huang, Ting Gui, Yaxin Yang, Tingting Feng, Nikolay T. Tzvetkov, Tao Xu, Zhibo Gai, Ying Zhou, Jingjie Zhang, Atanas G. AtanasovAbstractScavenger receptor class B type I (SR-BI) protein is an integral membrane glycoprotein. SR-BI is emerging as a multifunctional protein, which regulates autophagy, efferocytosis, cell survival and inflammation. It is well known that SR-BI plays a critical role in lipoprotein metabolism by mediating cholesteryl esters selective uptake and the bi-directional flux of free cholesterol. Recently, SR-BI has also been identified as a potential marker for cancer diagnosis, prognosis, or even a treatment target. Natural products are a promising source for the discovery of new drug leads. Multiple natural products were identified to regulate SR-BI protein expression. There are still a number of challenges in modulating SR-BI expression in cancer and in using natural products for modulation of such protein expression. In this review, our purpose is to discuss the relationship between SR-BI protein and cancer, and the molecular mechanisms regulating SR-BI expression, as well as to provide an overview of natural products that regulate SR-BI expression.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research