Keep calm and beam on? Unmet needs in radiotherapy and deep brain stimulation

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPI) was approved in 2002 as a treatment option for Parkinson's disease (PD), although it had been in use since the 1980s. Since then, more than 160,000 patients worldwide have received DBS, and as the incidence of PD is rising sharply, the number of people with PD who have undergone DBS will also increase. Importantly, an additional effect of longevity (related in part to deployment of advanced treatments for PD [1]), the likelihood increases of encountering a co-occurrence of cancer in patients treated with DBS.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research

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We reported DEGs with a nominal p-value of 0.8. The network construction was created using blockwiseModules function for consideration of computer efficiency. The module detection criteria were as follows: minimum module size of 50, deepsplit of 4, and merge threshold of 0.25. The merged modules were then summarized with module eigengene (ME) correlations>0.75. MEs were defined by their first principal component and were labeled with different colors as module names in the Results section. After the modules were generated, we conducted different enrichment analysis to explore the functional interpretation of genes withi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion The key problem with the ND field is the lack of understanding in the events preceding the development of protein-based markers – such as Tau – currently used to diagnose NDs. By this stage, the diseases become more difficult to treat. SncRNAs play an important regulatory role in the maintenance of the homeostatic brain. Therefore, changes in their concentration levels can be indicative of mechanistic changes that could precede protein-based markers. One single sncRNA biomarker is unlikely to differentiate between diseases. However, a combination of sncRNA biomarkers could be illustrative of the me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
We describe a 62-year-old female patient with advanced Parkinson's disease (PD) who was dependent on bilateral subthalamic nucleus (STN) DBS. She was diagnosed with cancer in her left breast. To avoid difficulties in imaging studies, surgery, and radiotherapy related to the breast cancer, bilateral pulse generators for STN DBS previously implanted in the anterior chest wall were repositioned to the anterior abdominal wall with replacement of long extension cables. During mastectomy and the relocation of the pulse generators, we were not aware of the risks of an open circuit and neuroleptic malignant-like syndrome due to ou...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
CONCLUSIONSSeven of 8 patients with unilateral STN DBS became candidates for second surgery before battery replacement surgery of the first implanted device. Baseline asymmetry alone may not predict appropriate candidates for unilateral STN DBS. This study provides further evidence that, from a long-term perspective, initial simultaneous bilateral STN DBS should be considered for PD patients with prominently asymmetrical motor symptoms. PMID: 30497175 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Tags: J Neurosurg Source Type: research
Background We undertook this study to identify patients with Parkinson disease (PD) with no or rare falls who may progress to frequent falling by their next annual follow-up visit. Methods We analyzed data in the National Parkinson Foundation Quality Improvement Initiative database to identify factors predicting which patients with PD with no or rare falls at the baseline visit will report at least monthly falls at the annual follow-up visit. Multivariable models were constructed using logistic regression. Variables were introduced in 4 blocks: in the 1st block, variables present at or before the baseline visit were enter...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Gait disorders/ataxia, Parkinson's disease/Parkinsonism, Cohort studies, Natural history studies (prognosis) Research Source Type: research
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
French biomedical research center Clinatec said today that it has raised $10.6 million (€10 million) to support research for diagnosis and treatment of neurodegenerative diseases, cancer and motor disabilities. The Grenoble-based incubator said that the campaign began in October 2015, led by a founding donor, the Edmond Safra Foundation, which pledged to match up to €5 million in donations. Clinatec is led by CEO Alim-Louis Benabid, a neurosurgeon and a biophysics professor at Université Joseph Fourier in Grenoble. Clinatec also highlighted upcoming clinical developments, including an implant that captures...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Business/Financial News Funding Roundup Implants Neurological Neuromodulation/Neurostimulation Clinatec Source Type: news
To effectively combat the scourge of neurodegenerative and other crippling diseases, we require the careful and considered use of nonhuman primatesNonhuman primates have long played a key role in life-changing medical advances. A recent white paper by nine scientific societies in the US produced a list of 50 medical advances from the last 50 years made possible through studies on nonhuman primates. These included: treatments for leprosy, HIV and Parkinson ’s; the MMR and hepatitis B vaccines; and earlier diagnosis and better treatment for polycystic ovary syndrome and breast cancer.The biological similarities between...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Science Animal welfare Animals World news Animal experimentation Source Type: news
ABSTRACT Functional radiosurgery has advanced steadily during the past half century since the development of the gamma knife technique for treating intractable cancer pain. Applications of radiosurgery for intracranial diseases have increased with a focus on understanding radiobiology. Currently, the use of gamma knife radiosurgery to ablate deep brain structures is not widespread because visualization of the functional targets remains difficult despite the increased availability of advanced neuroimaging technology. Moreover, most existing reports have a small sample size or are retrospective. However, increased experience...
Source: Movement Disorders - Category: Neurology Authors: Tags: Review Source Type: research
The FDA today released its list of the pre-market approvals it granted for medical devices in November 2015: Summary of PMA Originals &Supplements Approved Originals: 3 Supplements: 69 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 30 Total On Hold: 27 Summary of PMA Supplements Under Review Total Under Review: 583 Total Active: 433 Total On Hold: 150 Summary of All PMA Submissions Originals: 4 Supplements: 75 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 69 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 193.4 FDA Time...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news
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