Tolerance and dependence following chronic alprazolam treatment: quantitative observation studies in female rhesus monkeys

ConclusionsChronic alprazolam treatment resulted in rapid tolerance to some behaviors (e.g., deep sedation) but no tolerance to others (e.g., rest/sleep posture). Physical dependence was observed via both spontaneous and precipitated withdrawal. Based on previous research, these phenomena may reflect differential plasticity at GABAA receptor subtypes.

http://link.springer.com/10.1007/s00213-019-05447-1

Source: Psychopharmacology - January 10, 2020 Category: Psychiatry Source Type: research