7. Puberty as a Window of Susceptibility for Breast Cancer Risk: Exploring the Physiologic Mechanisms

Earlier onset of menarche is consistently noted as a risk marker for breast cancer. For example, risk of pre-menopausal breast cancer decreased by 9% for each year that menarche is delayed. Other pubertal milestones have also been associated with risk of breast cancer, including peak height velocity (PHV) and age of PHV. The hormonal environment, including sex steroids and growth hormone, change rapidly during puberty, and others have proposed the estrone:androstenedione ratio (E:A ratio) may provide an index of aromatase activity.

Source: Journal of Adolescent Health - January 11, 2020 Category: Child Development Authors: Frank M. Biro, Bin Huang, Catherine M. Gordon, Susan M. Pinney Tags: Platform Research Presentation: Vaccines/Screening/Wellness Source Type: research