251. Practice-Level Barriers and Facilitators to Universal Chlamydia Screening Among Young Women in Pediatric Primary Care Clinics

Chlamydia trachomatis infection is highly prevalent among adolescents and young adults with potential for long-term health consequences, especially for young women. Despite a strong recommendation by the United States Preventive Services Task Force for routine chlamydia screening in sexually active women aged 24 years or less, screening rates remain low, particularly in pediatric primary care practices. Prior research has advanced our understanding of patient-, family- and provider-level barriers to screening young women, including inadequate assessment of patients ’ sexual history and concerns about confidentiality.
Source: Journal of Adolescent Health - Category: Child Development Authors: Source Type: research

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Publication date: Available online 19 May 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Maria-Francesca Manca, Laurence Rochat Stettler, Jean-François Carod, Camille Agostini, Anne Jolivet
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 May 2020Source: Microbes and InfectionAuthor(s): Jeewan Thapa, Kent Hashimoto, Saori Sugawara, Ryoya Tsujikawa, Torahiko Okubo, Shinji Nakamura, Hiroyuki Yamaguchi
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: 19 May 2020Source: Cell Reports, Volume 31, Issue 7Author(s): Audrey Xavier, Munir A. Al-Zeer, Thomas F. Meyer, Oliver Daumke
Source: Cell Reports - Category: Cytology Source Type: research
A new 30-minute point-of-care test using self-collected vaginal swabs works as well as lab-based molecular diagnostic tests for detecting chlamydia and gonorrhea, new findings show.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Family Medicine/Primary Care News Source Type: news
In this study, we attempted to explore the role of the only secreted plasmid-encoded protein pORF5 of C. trachomatis between UPR and autophagy induction. The results showed that three branches of UPR (PERK, IRE1, and ATF6) were activated by pORF5. pORF5-induced autophagy was repressed by UPR inhibitors GSK2606414 and 4μ8C, while the autophagy inhibition was failed to influence pORF5-induced UPR significantly. MAPK/ERK inhibitor PD98059 partially suppressed the pORF5-induced autophagy, but had little effect on UPR, indicating that pORF5 actives UPR to induce autophagy via the MAPK/ERK signaling pathway. These observ...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
The cryptic plasmid pCM is critical for chlamydial colonization in the gastrointestinal tract. Nevertheless, orally inoculated plasmid-free Chlamydia sp. was still able to colonize the gut. Surprisingly, orally inoculated Chlamydia sp. deficient in only plasmid-encoded pGP3 was no longer able to colonize the gut. A comparison of live organism recoveries from individual gastrointestinal tissues revealed that pGP3-deficient Chlamydia sp. survived significantly better than plasmid-free Chlamydia sp. in small intestinal tissues. However, the small intestinal pGP3-deficient Chlamydia sp. failed to reach the large intestine, exp...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host-Associated Microbial Communities Source Type: research
Apoptotic cell death can be an efficient defense reaction of mammalian cells infected with obligate intracellular pathogens; the host cell dies and the pathogen cannot replicate. While this is well established for viruses, there is little experimental support for such a concept in bacterial infections. All Chlamydiales are obligate intracellular bacteria, and different species infect vastly different hosts. Chlamydia trachomatis infects human epithelial cells; Parachlamydia acanthamoebae replicates in amoebae. We here report that apoptosis impedes growth of P. acanthamoebae in mammalian cells. In HeLa human epithelial cell...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research
Higher education member Bill Acharjee (above) works at Solent University in Southampton as a research governance officer, with the task of ensuring that students and academics maintain ethical standards while they conduct their research projects. He’s thoughtful, conscientious. And while working from home during the COVID-19 crisis, he has a very sobering thought. “A world without universities would be tragic,” he says. “I just can’t comprehend it.” But there’s a very real danger some may struggle to survive, Mr Acharjee feels, if the government continues to refuse to come to the a...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article News coronavirus higher education Covid-19 Source Type: news
Authors: D'Aiuto C, Valderrama A, Byrns M, Boucoiran I Abstract OBJECTIVES: To analyze risk factors for the presence of sexually transmitted and blood-borne infections (STBBIs) in pregnancy and to determine whether pregnant women with STBBIs are more likely to experience adverse pregnancy outcomes. METHODS: This retrospective cohort study involved analyzing the electronic records of 3460 pregnant women followed at Sainte-Justine Hospital in Montréal, Québec, between March 2017 and January 2019. An outcome is defined as a pregnancy where the woman has at least one positive laboratory result for chl...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Abstract The purpose of this study was to estimate the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in western French Guiana and to analyze associated factors with both infections. A retrospective study was conducted in a sexually transmitted infections (STI) clinic in 2017. Women (n=338) were tested by real-time PCR for vaginal, anal and throat CT and NG infections. Men (n=192) were evaluated using urine specimens. Socio-demographic and sexual behaviour data were collected by nurses with a structured questionnaire. The prevalence of CT and NG infections among women were 24.3%...
Source: Braz J Infect Dis - Category: Infectious Diseases Authors: Tags: Braz J Infect Dis Source Type: research
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