Transient increase in international normalized ratio (INR) and bleeding risk following Alendronate sodium in elderly patients on warfarin: Two case reports

Conclusion: Alendronate sodium can transiently increase the INR over 50%, induce spontaneous ecchymoses and petechiae in the skin of aged male osteoporosis patients with AF who took warfarin. Clinicians should pay enough attention when using alendronate sodium on these kinds of patients and be aware of the consequent potential bleeding risk.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Related Links:

This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with.  In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Eric Weinhandl JAMA medical research public health Public Policy public policy research Source Type: blogs
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Kehinde S. Olaniyi, Oluwatobi A. Amusa
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 May 2020Source: PhytomedicineAuthor(s): Nani Wang, Pingcui Xu, Xuping Wang, Weixuan Yao, Binjie Wang, Yuanzhao Wu, Dan Shou
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Condition:   Periodontal Diseases Intervention:   Drug: Sodium hypochlorite gel application Sponsor:   University of Messina Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Atrial Fibrillation Intervention:   Procedure: Thoracoscopic Atrial fibrillation Ablation Sponsor:   Nanjing Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Osteoporosis;   Degenerative Lumbar Diseases Intervention:   Sponsor:   Peking University Third Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In Sketchy they say Sodium Bicarbonate is used to treat TCA overdose. One of the reasons they say is because it increases serum pH which favors the non-ionized form of the drug. Why is this? I thought increase serum pH> less H+. Then to compensate for this decrease in H+, wouldn't TCA ionize more to replace to lost H+ ions?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Abstract We used five types of surfactants assisted with sodium salts, including sodium tartrate (ST), sodium chloride (SC), and humic acid sodium (HAS) as auxiliary agents for soil washing to remove diesel from contaminated soil. Decontamination enhancement of diesel polluted soil washing with biosurfactant and H2O2 was examined, which showed higher effectiveness for newly contaminated soil. An increase in temperature and sodium salt addition exhibited a profound enhancement in diesel removal from aged contaminated soils. Compared to ST and SC, HAS exhibited a higher removal efficiency with saponin washing for ag...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Abstract Three spectrophotometric methods have been developed and compared for the quantification of low concentrations (0.03-63 μM) of aqueous permanganate in neutral pH conditions. Although permanganate is a widely used oxidant in drinking water and wastewater treatment, no widely accepted method of quantification has been reported to date. While one method presented does not require the need for any reagent chemicals (direct spectrophotometric analysis), it yielded a relatively low molar absorption coefficient of 3340 M-1 cm-1 at 525 nm and a level of detection (LOD) and quantification (L...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
More News: Atrial Fibrillation | Bleeding | Cardiology | Cardiovascular | Coumadin | DEXA Scan | Heart | Internal Medicine | Orthopaedics | Osteoporosis | Skin | Sodium | Warfarin