The role of mitochondria in redox signaling of muscle homeostasis

Publication date: Available online 11 January 2020Source: Journal of Sport and Health ScienceAuthor(s): Li Li Ji, Dongwook Yeo, Chounghun Kang, Tianou ZhangAbstractIn the past, contraction-induced production of reactive oxygen species (ROS) has been implicated in oxidative stress to skeletal muscle. As research advances, clear evidence has revealed a more complete role of ROS under both physiological and pathological conditions. Central to the role of ROS is the redox signaling pathways that control exercise-induced major physiological and cellular responses and adaptations, such as mitochondrial biogenesis, mitophagy, mitochondrial morphological dynamics, antioxidant defense, and inflammation. The current review focuses on how muscle contraction and immobilization may activate or inhibit redox signaling and their impact on muscle mitochondrial homeostasis and physiological implications.
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research