Emerging Potential of Naturally Occurring Autophagy Modulator against Neurodegeneration.

CONCLUSION: Existing in vitro and in vivo data are promising, and highlight that naturally-occurring autophagy-regulating compounds play an important role for the prevention and treatment of neurodegenerative disorders. PMID: 31914904 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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Publication date: Available online 17 February 2020Source: LWTAuthor(s): Josiana M. Mar, Laiane S. Silva, Maxwaldo da S. Rabelo, Magno P. Muniz, Sergio M. Nunomura, Renilto F. Correa, Valdely Ferreira Kinupp, Pedro H. Campelo, Jaqueline de A. Bezerra, Edgar A. SanchesAbstractBioactive compounds of Clidemia japurensis and Clidemia hirta juices were encapsulated in maltodextrin (MD) of different dextrose equivalents (DE – MD10, MD20 AND MD30). Microparticles containing the encapsulated juices were obtained by freeze-drying process. The stability of the encapsulated bioactive compounds was evaluated under different rela...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Dalton Trans., 2020, Advance Article DOI: 10.1039/C9DT04540F, PaperEleftherios Halevas, Barbara Mavroidi, Orestis Antonoglou, Antonios Hatzidimitriou, Marina Sagnou, Anastasia A. Pantazaki, George Litsardakis, Maria Pelecanou Novel, first time crystallographically characterized complexes of Ga(III) with the flavonoid chrysin with cytotoxic and ROS-generating activities. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThe strength of respiratory muscles is measured in terms of pressure, being the gradient that moves flow/volume to ventilate the lungs.Sniff test is a technically simple voluntary test that quantifies the strength of inspiratory muscles. Sniff nasal inspiratory pressure (SNIP)1 is a non ‐invasive parameter extensively used in the clinical, being considered more natural and pleasant than maximal inspiratory pressure measurements. It solves the possible leak problems of the use of a mouthpiece, particularly in neuromuscular patients2,3. In amyotrophic lateral sclerosis, for example, SNIP is a predictor of survival and tracheostomy4,5.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: LETTER TO THE EDITOR Source Type: research
Condition:   Friedreich Ataxia Intervention:   Drug: Etravirine Tablets Sponsors:   IRCCS Eugenio Medea;   University of Rome Tor Vergata Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Liposomal nanoparticles may improve the solubility and bioavailability of quercetin in liver. Furthermore, nanoliposomal quercetin could effectively protect rats against acute liver injury and may be a new hepatoprotective and therapeutic agent for patients with liver diseases. PMID: 32059743 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
slash;rklund Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s and Alzheimer’s diseases contain a clinically diverse spectrum of tauopathies. Studies of case records of various tauopathies may reveal clinical phenotype characteristics of the disease. In addition, improved understanding of different tauopathies would disclose environmental factors, such as xenobiotics and trace metals, that can precipitate or modify the progression ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
AbstractIn amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), spinal and lower brainstem motor neurons degenerate, but some motor neuron subtypes are spared, including oculomotor neurons (OMNs). The mechanisms responsible for this selective degeneration are largely unknown, but the molecular signatures of resistant and vulnerable motor neurons are distinct and offer clues to neuronal resilience and susceptibility. Here, we demonstrate that healthy OMNs preferentially expressSynaptotagmin 13 (SYT13) compared to spinal motor neurons. In end-stage ALS patients,SYT13 is enriched in both OMNs and the remaini...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
ConclusionThe DMPFC subsystem was predominantly disrupted in the PD-MCI subgroup and may have the potential to discriminate PD with MCI.
Source: Neuroradiology - Category: Radiology Source Type: research
eh Adenan Centella asiatica (C. asiatica) is one of the medicinal plants that has been reported to exert comprehensive neuroprotection in vitro and in vivo. In view of this, the present study was performed to investigate the effect of ethanolic extract of C. asiatica, designated as raw-extract of C. asiatica (RECA) in reducing the acetylcholinesterase (AChE), inflammations, and oxidative stress activities via both in vitro (SH-SY5Y and RAW 264.7 cells) and in vivo (Sprague Dawley rats). Quantitative high-performance liquid chromatography analysis reveals that RECA contains a significantly high proportion of glycosid...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, polydimethylsiloxane-based microfluidic devices were designed, fabricated, and characterized to produce silk particles through self-association of silk when exposed to PVA. Three main variables resulted in differences in particle size and size distribution, or polydispersity index (PDI). Utilizing a co-flow microfluidic device decreased the PDI of the silk particles as compared to an emulsion-based method (0.13 versus 0.65, respectively). With a flow-focusing microfluidics device, lowering the silk flow rate from 0.80 to 0.06 mL/h resulted in a decrease in the median particle size from 6.8 to 3.0 μm a...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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