Evaluation of Cumulative and Conditional Antibiotic Release from Vancomycin-Embedded Fibrin Sealant and Its Antibacterial Activity : An In Vitro Study.

CONCLUSION: This study suggests that fibrin sealant can provide an efficient vehicle for antibiotic drug release in a wide range of neurosurgical procedures and the safe and effective therapeutic dose will be at the concentration embedded of 4.167 mg/disc or more of vancomycin. PMID: 31916426 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31916426?dopt=Abstract

Source: Journal of Korean Neurosurgical Society - January 11, 2020 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research