Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway

Insulin deficiency in type 2 diabetes mellitus (DM) involves a decline in both pancreatic β-cell mass and function. Enhancing β-cell preservation represents an important therapeutic strategy to treat type 2 DM. Far-infrared (FIR) radiation has been found to induce promyelocytic leukemia zinc finger protein (PLZF) activation to protect the vascular endothelium in diabetic mice. The infl uence of FIR on β-cell preservation is unknown. Our previous study reveals that the biologically effective wavelength of FIR is 8–10 μm.

Source: Metabolism - Clinical and Experimental - January 9, 2020 Category: Biomedical Science Authors: Yung-Ho Hsu, Yen-Cheng Chen, Yu-Wei Chen, Tzu-Hsuan Chiu, Yung-Ting Kuo, Cheng-Hsien Chen Source Type: research