Septin architecture and function in budding yeast.

Septin architecture and function in budding yeast.
Biol Chem. 2019 Dec 01;:
Authors: Farkašovský M
Abstract
The septins constitute a conserved family of guanosine phosphate-binding and filamentforming proteins widespread across eukaryotic species. Septins appear to have two principal functions. One is to form a cortical diffusion barrier, like the septin collar at the bud neck of Saccharomyces cerevisiae, which prevents movement of membrane-associated proteins between the mother and daughter cells. The second is to serve as a polymeric scaffold for recruiting the proteins required for critical cellular processes to particular subcellular areas. In the last decade, structural information about the different levels of septin organization has appeared, but crucial structural determinants and factors responsible for septin assembly remain largely unknown. This review highlights recent findings on the architecture and function of septins and their remodelling with an emphasis on mitotically-dividing budding yeasts.
PMID: 31913844 [PubMed - as supplied by publisher]

Source: Biological Chemistry - January 10, 2020 Category: Chemistry Tags: Biol Chem Source Type: research