Cancers, Vol. 12, Pages 169: Differential Depletion of Bone Marrow Resident B-ALL after Systemic Administration of Endosomal TLR Agonists
In this study, we compare the organ-specific depletion of human and mouse primary B-ALL cells after systemic administration of endosomal TLR agonists. Despite comparable splenic responses, only the TLR9 agonist induced strong innate immune responses in the bone marrow and achieved a near-complete elimination of B-ALL cells. This pattern of response was associated with the most significantly prolonged disease-free survival. Overall, our findings identify innate immune activity in the bone marrow that is associated with durable TLR-induced protection against B-ALL outgrowth.
Source: Cancers - Category: Cancer & Oncology Authors: Sumin Jo Abbas Fotovati Jesus Duque-Afonso Michael L. Cleary Peter van den Elzen Alix E. Seif Gregor S.D. Reid Tags: Article Source Type: research
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