Certolizumab pegol for the treatment of psoriatic arthritis and plaque psoriasis.

Certolizumab pegol for the treatment of psoriatic arthritis and plaque psoriasis. Expert Rev Clin Immunol. 2020 Jan 09;: Authors: Esposito M, Carubbi F, Giunta A, Alunno A, Giacomelli R, Fargnoli MC Abstract Introduction: Certolizumab pegol (CZP) is a Fc-free PEGylated TNF-α inhibitor approved for the treatment of psoriatic arthritis (PsA) and plaque psoriasis in many countries. It demonstrated favorable results in PsA in terms of improvement in peripheral arthritis, dactylitis and enthesitis in a phase III trial (RAPID-PSA) and in real-life experiences. Recently, 3 phase III randomized clinical trials (CIMPASI-1, CIMPASI-2, CIMPACT) showed significant, clinically meaningful, and sustained improvements in signs and symptoms of moderate-to-severe plaque psoriasis as well as in quality of life parameters as compared to placebo and etanercept, mainly for the higher dose, both in the short- and long-term period.Areas covered: We reviewed the structure and the mechanism of action of CZP, and critically analyzed data from clinical trials and real-life, concerning its efficacy and safety in all aspects of the psoriatic disease. We designed a comprehensive literature search on this topic, by a review of published articles in indexed international journals up until 31st July 2019.Expert opinion: CZP demonstrated positive results in several domains of psoriatic disease, also in patients previously exposed to other TNF-α inhibitors and in pat...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research