Michael J. Fox Foundation for Parkinson's Research Target Validation Program

Michael J. Fox Foundation for Parkinson's Research Target Validation Program Spring 2014 Review Cycle Pre-Proposals Due: October 30, 2013 – 6pm US ET Full Proposal Invitations: November 20,  2013 Full Proposals Due (by invite only): January 15, 2014– 6pm US ET Anticipated Award Announcement: March 2014 Anticipated Funding: April 2014 The Target Validation program supports work to determine whether manipulation of a defined biological target provides a disease-relevant beneficial outcome in a whole animal, mammalian model of PD. MJFF does not have any pre-conceived preferences for particular targets submitted to the Target Validation program. However, we recommend applicants consider the following: Target Selection The target should be clearly defined, such as: A specific gene A structural/functional feature of a protein (e.g., its enzymatic activity, protein conformation or ability to interact with other proteins) Proposals seeking to manipulate global pathways without a clear target are not encouraged Target Manipulation Applicants may propose a variety of methods to manipulate a target, including but not limited to: Use of pharmacological tools Supporting data/explanation of the proposed pharmacological tool must be addressed in the body of the proposal.  Parameters that should be discussed include: Selectivity for the target of interest Potency Pharmacokinetic/Pharmaco...
Source: ScanGrants feed - Category: Research Authors: Source Type: funding