Do Patients With Inflammatory Bowel Disease Have a Higher Postoperative Risk of Venous Thromboembolism or Do They Undergo More High-risk Operations?
Conclusions: Postoperative VTE risk varies widely by the operation performed, and a diagnostic indication of CD or UC does not play a role. Extended duration VTE prophylaxis should be considered in all patients undergoing high-risk operations, regardless of their underlying diagnosis.
Clostridioides difficile (C. difficile) definition: “a germ (bacteria) that causes life-threatening diarrhea. It is usually a side-effect of taking antibiotics.” According to the Centers for Disease Control and Prevention (CDC) 2015 report, over 100,000 C. difficile infections (CDI) occur in the U.S. nursing home population yearly. Approximately 29,000 patients died 30 days post-diagnosis of CDI with about 15,000 deaths being directly attributable to CDI; over 80% of mortalities related to CDI happen in residents aged 65 and above.
Authors: Nyamu DG, Guantai AN, Osanjo GO, Godman B, Aklillu E Abstract Background: Patients' profiles affect the outcome with warfarin; however, this data, and its implications, is scarce in resource-poor countries such as Kenya without access to pharmacogenetics or regular INR testing.Objectives: To characterize the profiles of patients on long-term warfarin therapy and subsequently use the findings to guide future anticoagulation management.Methods: Cross-sectional study undertaken among 180 adult patients receiving warfarin therapy in anticoagulation clinics at a leading referral hospital in Kenya. Sociodemograp...
Condition: Inflammatory Bowel Diseases Intervention: Genetic: PCR-RFLP Sponsor: Assiut University Not yet recruiting
Conclusions: Our study further expands the spectrum of the sequence variants reported in the DGKE gene and also indicates that different races may have different DGKE variants. Moreover, the altered structures and conformations, caused by DGKE mutations, disrupt the binding of DGKE with its partners, and leading to the occurrence of aHUS. PMID: 32091318 [PubMed - in process]
CONCLUSIONS: The prevalence of AF in CS should be studied more precisely, both in a scientific way and at the individual patient's level. PMID: 32096188 [PubMed - in process]
The increase in severe maternal morbidity and mortality in the United States correlates with a significant rise in U.S. cesarean birth rates from 5.5% in 1970 to a rate of 31.9% of all births in 2018, far beyond the World Health Organization goal of 10% to 15%. Three key contributors to maternal morbidity and mortality related to cesarean birth include complications of hemorrhage, surgical site infection, and venous thromboembolism. All women should be screened for risk factors associated with these major complications during the antepartum, intrapartum, and postpartum period to assure the availability of immediate resourc...
Do patients with inflammatory bowel disease have an increased risk of adverse maternal, placental, or obstetric-related pregnancy outcomes?Alimentary Pharmacology &Therapeutics
In this study we demonstrate a vital role for Mbd2 in regulating murine colonic inflammation. Mbd2-/- mice displayed dramatically worse pathology than wild type controls during dextran sulphate sodium (DSS) induced colitis, with increased inflammatory (IL-1 β+) monocytes. Profiling of mRNA from innate immune and epithelial cell (EC) populations suggested that Mbd2 suppresses inflammation and pathology via control of innate-epithelial cell crosstalk and T cell recruitment. Consequently, restriction of Mbd2 deficiency to CD11c+ dendritic cells and macro phages, or to ECs, resulted in increased DSS colitis severity. Our ...