Efficacy of Acellular Dermal Matrix in Capsular Contracture of Implant-Based Breast Reconstruction: A Single-Arm Meta-analysis
AbstractBackgroundA large number of clinical studies have suggested that acellular dermal matrix (ADM) can decrease the incidence of capsular contracture in implant-based breast reconstruction. Yet, there is currently no high-level epidemiological evidence to prove this. The goal of this meta-analysis was to clarify the efficacy of ADM in capsular contracture, and provide a reference value for plastic surgeons.MethodsWe systematically performed a search on PubMed, EMBASE, and the Cochrane Library to identify eligible studies from inception up to October 1, 2019. A random-effects model was used to obtain a pooled incidence rate. We conducted subgroup analysis according to geographic region, type of ADM, body mass index (BMI), duration of follow-up, and proportion of participants who have received radiotherapy.ResultsA total of 18 studies involving 2941 cases were included. Overall, the pooled incidence rate of capsular contracture was 2.4% (95% CI 1.2 –3.9%). The results from subgroup analyses indicated an even lower incidence in North America (1.6%, 95% CI 0.5–3.3%) and in human-derived ADM (HADM) (1.2%, 95% CI 0.2–3.0%). In addition, the results showed that the patients with BMI
Conclusions: The complication rates after breast augmentation with fat grafting are low and support fat grafting as an alternative to breast augmentation with implants. The rates of radiologic changes are high after fat grafting, but the changes do not seem to have any therapeutic consequences for the patients.
Conclusions: Omega-3 supplementation seems to be effective in reducing the occurrence of capsular formation, mainly through inhibition of the TGF-β pathway and impairment of collagen deposit. Omega-3 supplementation is a simple and promising method that could be used to prevent or at least reduce capsular contracture after silicone implant surgery.
Conclusions: The authors combined a novel surface implant classification system and gene profiling analysis to show that implant surface topography is a bioactive cue that can trigger gene expression changes in surrounding tissue, even in Baker grade I capsules. The authors’ new classification system avoids confusion regarding the word “texture,” and could be transposed to implant ranges of every manufacturer. This new classification could prove useful in studies on potential links between specific texturizations and the incidence of certain breast-implant associated complications.
(Wolters Kluwer Health) For women receiving breast implants during reconstructive or cosmetic breast surgery, scarring around the implant - called capsular contracture - is a common, costly, and painful complication. The anti-inflammatory effects of omega-3 fatty acids, found in fish oil, might help to avoid abnormal capsule formation suggests an experimental study in the March issue of Plastic and Reconstructive Surgery ® , the official medical journal of the American Society of Plastic Surgeons (ASPS).
This article provides recommendations for the appropriate utilization of these agents.Plastic Reconstructive Surgery-Global Open (PRS Global Open)
We present a case report of an adult woman with AKL-positive ALCL, diagnosed by endobronchial ultrasound-guided transbronchial needle aspirate (EBUS-TBNA).A 59-year-old women with no history of breast implants, was admitted for a four-month low back pain. Initially, the patient was treated for a spondyloarthropathy, but due to persistence of the symptoms, a lumbosacral MRI was performed, showing changes in morphology and signal intensity in the vertebral body of L3, along with edema and a paravertebral collection that affected the left psoas muscle, suggesting granulomatous spondylodiscitis. Chest CT-scan showed mild left ...
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It's a question that's surprisingly difficult to answer.
Publication date: Available online 14 February 2020Source: Materials Today: ProceedingsAuthor(s): Trinath Biswal, Sushant Kumar BadJena, Debabrata PradhanAbstractThe materials designed and developed to interact with the biological systems are called biomaterials. They are bioactive materials and easily compactable to the human tissue. They show good degree of biodegradability. They are commonly used in medicines, tissue engineering, manufacturing of human body parts and other manufacturing applications. The sustainability and biomaterials are co-complementary to each other and support the manufacturing/development of new s...
This study confirms the potentialities of both shaped micro-textured and round smooth implants in reconstructive surgery.