Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy

British Journal of Cancer, Published online: 10 January 2020; doi:10.1038/s41416-019-0682-4Accelerating development of high-risk neuroblastoma patient-derived xenograft models for preclinical testing and personalised therapy
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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Childhood cancer survivors (CCSs) from high-grade malignancies, such as high-risk neuroblastoma, have been increased, and second malignant neoplasm, becomes a serious problem for CCSs. However, detailed reports about rare types of second cancer such as gastric cancer remain limited. We herein reported a female patient who developed diffuse type gastric carcinoma after 21 years from completion of treatment to high-risk neuroblastoma. We reviewed the previous cohort studies for second gastrointestinal cancer in CCSs and the case reports with second gastric carcinoma for CCSs. We presumed second gastric cancer was refractory ...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research
In this study, two novel benzimidazolium salts consisting propane sulfonate order were integrated in high yields as N-heterocyclic carbene (NHC) precursors.The silver-NHC buildings were set up by responding 1-(2,2-dimethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium and 1-(2,2-diethoxyethyl)- 3-(propyl-3-sulfonate)benzimidazolium with silver oxide on average state. Gold-NHC edifices were acquired by means of transmetallation of their silver precursors with [AuCl{S(CH3)2}]. The structures of all mixes were completely portrayed by spectroscopic techniques (1H-NMR, 13C{1H} NMR , IR and elemental and further analyzed by DFT/...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
(Rice University) Rice University neurodevelopmental biologist Rosa Uribe has won a prestigious CAREER Award from the National Science Foundation to study neural crest cells, specialist stem cells that form the enteric nervous system and also cause neuroblastoma, the third most prevalent form of pediatric cancer in the U.S.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
In this study, polydimethylsiloxane-based microfluidic devices were designed, fabricated, and characterized to produce silk particles through self-association of silk when exposed to PVA. Three main variables resulted in differences in particle size and size distribution, or polydispersity index (PDI). Utilizing a co-flow microfluidic device decreased the PDI of the silk particles as compared to an emulsion-based method (0.13 versus 0.65, respectively). With a flow-focusing microfluidics device, lowering the silk flow rate from 0.80 to 0.06 mL/h resulted in a decrease in the median particle size from 6.8 to 3.0 μm a...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 13 February 2020Source: Pharmacological ResearchAuthor(s): Swadesh K. Das, Santanu Maji, Stephen L. Wechman, Praveen Bhoopathi, Anjan K. Pradhan, Sarmistha Talukdar, Devanand Sarkar, Joseph Landry, Chunqing Guo, Xiang-Yang Wang, Webster K. Cavenee, Luni Emdad, Paul B. FisherAbstractThe primary cause of cancer-related death from solid tumors is metastasis. While unraveling the mechanisms of this complicated process continues, our ability to effectively target and treat it to decrease patient morbidity and mortality remains disappointing. Early detection of metastatic lesions and approaches...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 12 February 2020Source: Cancer GeneticsAuthor(s): Iyad Sultan, Abdelghani Tbakhi
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
This study provides a novel methodologic approach for modelling the spontaneous metastatic cascade of human BM metastasis formation in mice. Moreover, our data indicate that putative bone-metastatic features get rapidly lost upon routine cell culture.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract Outcomes of treatment for malignant pediatric tumors including leukemia are improving by conventional multimodal treatment with strong chemotherapy, surgical resection, radiotherapy, and bone marrow transplantation. However, patients with advanced neuroblastoma, metastatic Ewing's sarcoma family of tumor (ESFT), and metastatic osteosarcoma continue to have an extremely poor prognosis. Therefore novel therapeutic strategies are urgently needed to improve their survival. Apoptotic cell death is a key mechanism for normal cellular homeostasis. Intact apoptotic mechanisms are pivotal for embryonic development...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
(Kobe University) Neuroblastoma is a cancer that affects children, characterized by solid tumors that develop from immature nerve cells. Over 50% of patients with high-risk neuroblastoma experience tumor relapse/regrowth.A research group led by Professor NISHIMURA Noriyuki (Graduate School of Health Sciences, Kobe University) has developed a new method to monitor the residual disease after treatment in high-risk neuroblastoma patients. The method could be utilized to evaluate treatment response and facilitate early diagnosis of tumor relapse/regrowth.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent nee...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
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