Potential of phytochemicals as immune-regulatory compounds in atopic diseases: a review.

Potential of phytochemicals as immune-regulatory compounds in atopic diseases: a review.
Biochem Pharmacol. 2020 Jan 03;:113790
Authors: Sharma S, Naura AS
Abstract
Atopic diseases (atopic dermatitis, asthma and allergic rhinitis) affects a huge number of people around the world and their incidence rate is on rise. Atopic dermatitis (AD) is more prevalent in paediatric population which sensitizes an individual to develop allergic rhinitis and asthma later in life. The complex pathogenesis of these allergic diseases though involves numerous cellular signalling pathways but redox imbalance has been reported to be critical for induction/perpetuation of inflammatory process under such conditions. The realm of complementary and alternative medicine has gained greater attention because of the reported anti-oxidant/anti-inflammatory properties. Several case studies of treating atopic diseases with homeopathic remedies have provided positive results. Likewise, pre-clinical studies suggest that various natural compounds suppress allergic response via exhibiting their anti-oxidant potential. Despite the reported beneficial effects of phytochemicals in experimental model system, the clinical success has not been documented so far. It appears that poor absorption and bioavailability of natural compounds may be one of the reasons for realizing their full potential. The current paper throws light on impact of phytochemicals in the redox linked cel...

Source: Biochemical Pharmacology - January 2, 2020 Category: Drugs & Pharmacology Authors: Sharma S, Naura AS Tags: Biochem Pharmacol Source Type: research